Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:Eta-1
gptkb:Secreted_Phosphoprotein_1 Bone sialoprotein I |
| gptkbp:associatedWith |
gptkb:cancer
atherosclerosis autoimmune diseases kidney stones |
| gptkbp:binds |
gptkb:integrins
gptkb:CD44 |
| gptkbp:discoveredIn |
1986
|
| gptkbp:encodedBy |
SPP1 gene
|
| gptkbp:expressedIn |
gptkb:T_cells
macrophages epithelial cells osteoblasts |
| gptkbp:foundIn |
humans
mice other mammals |
| gptkbp:function |
wound healing
inflammation cell adhesion immune response regulation bone remodeling tumor progression |
| https://www.w3.org/2000/01/rdf-schema#label |
Osteopontin
|
| gptkbp:locatedOnChromosome |
chromosome 4q22.1 (human)
|
| gptkbp:location |
gptkb:bone
gptkb:kidney extracellular matrix immune cells |
| gptkbp:molecularWeight |
~44 kDa
|
| gptkbp:postTranslationalModification |
phosphorylation
glycosylation proteolytic cleavage |
| gptkbp:role |
gptkb:Th1_immune_response
angiogenesis cell migration metastasis fibrosis tissue repair inhibition of apoptosis bone mineralization calcification inhibition macrophage chemotaxis osteoclast activation |
| gptkbp:UniProtID |
P10451
|
| gptkbp:bfsParent |
gptkb:SPP1
|
| gptkbp:bfsLayer |
7
|