|
gptkbp:instanceOf
|
gptkb:drug
proton pump inhibitor
|
|
gptkbp:approvedBy
|
1988
|
|
gptkbp:ATCCode
|
A02BC01
|
|
gptkbp:brand
|
gptkb:Losec
gptkb:Prilosec
Zegerid
|
|
gptkbp:CASNumber
|
73590-58-6
|
|
gptkbp:contraindication
|
hypersensitivity to omeprazole
|
|
gptkbp:developedBy
|
gptkb:Astra_AB
|
|
gptkbp:drugClass
|
proton pump inhibitor
|
|
gptkbp:drugInteraction
|
gptkb:phenytoin
gptkb:warfarin
gptkb:clopidogrel
gptkb:ketoconazole
gptkb:methotrexate
gptkb:atazanavir
gptkb:diazepam
|
|
gptkbp:eliminationHalfLife
|
0.5–1 hour
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:genericAvailable
|
yes
|
|
gptkbp:hasMolecularFormula
|
C17H19N3O3S
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Omeprazole
|
|
gptkbp:legalStatus
|
prescription only
over-the-counter (in some countries)
|
|
gptkbp:mechanismOfAction
|
inhibits H+/K+ ATPase in gastric parietal cells
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:patentExpired
|
yes
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:riskFactor
|
long-term use may cause hypomagnesemia
long-term use may cause vitamin B12 deficiency
long-term use may increase risk of bone fractures
may mask symptoms of gastric cancer
may increase risk of Clostridioides difficile infection
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
nausea
diarrhea
abdominal pain
constipation
dizziness
headache
rash
flatulence
|
|
gptkbp:usedFor
|
gptkb:Zollinger-Ellison_syndrome
gptkb:erosive_esophagitis
gptkb:gastroesophageal_reflux_disease
gptkb:peptic_ulcer_disease
Helicobacter pylori eradication
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
|
gptkbp:bfsParent
|
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|