|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:SLC22A1
solute carrier family 22 member 1
|
|
gptkbp:associated_drug_response
|
metformin pharmacokinetics
|
|
gptkbp:Entrez_Gene_ID
|
6580
ENSG00000183083
|
|
gptkbp:expressedIn
|
gptkb:kidney
liver
intestine
|
|
gptkbp:fullName
|
gptkb:Organic_cation_transporter_1
|
|
gptkbp:function
|
transports organic cations across cell membranes
|
|
gptkbp:gene
|
gptkb:SLC22A1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
OCT1
|
|
gptkbp:inhibitors
|
gptkb:verapamil
cimetidine
quinidine
|
|
gptkbp:locatedOnChromosome
|
6q25.3
|
|
gptkbp:location
|
basolateral membrane of hepatocytes
|
|
gptkbp:molecularWeight
|
~61 kDa
|
|
gptkbp:mutationAssociatedWith
|
alters drug response
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:publicTransit
|
gptkb:SLC22
|
|
gptkbp:significance
|
pharmacogenomics
|
|
gptkbp:structure
|
12 transmembrane domains
|
|
gptkbp:substrate
|
gptkb:metformin
gptkb:choline
gptkb:tetraethylammonium
methylhistamine
|
|
gptkbp:UniProtID
|
O15245
|
|
gptkbp:bfsParent
|
gptkb:solute_carrier_family_22
gptkb:SLC22A1
gptkb:O00750
|
|
gptkbp:bfsLayer
|
7
|