|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:OCT1
OTF1
POU domain, class 2, transcription factor 1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:binds
|
octamer motif (ATGCAAAT)
|
|
gptkbp:discoveredBy
|
Staudt et al.
|
|
gptkbp:encodes
|
POU domain, class 2, transcription factor 1
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000119922
5451
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1986
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPOUDomain
|
yes
|
|
gptkbp:hasPOUHomeodomain
|
yes
|
|
gptkbp:hasPOUSpecificDomain
|
yes
|
|
gptkbp:HGNC_ID
|
9210
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
POU2F1
|
|
gptkbp:interactsWith
|
gptkb:SP1
gptkb:CREB-binding_protein
gptkb:BRCA1
gptkb:p53
gptkb:NF-κB
|
|
gptkbp:involvedIn
|
cell differentiation
development
immune response
|
|
gptkbp:isHumanGene
|
yes
|
|
gptkbp:length
|
743 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
1q24.2
|
|
gptkbp:molecularWeight
|
~75 kDa
|
|
gptkbp:OMIM
|
164175
|
|
gptkbp:orthologInMouse
|
Pou2f1
|
|
gptkbp:regulates
|
gptkb:POU_family
apoptosis
DNA repair
gene expression
cell cycle
immunoglobulin gene expression
histone gene expression
HLA gene expression
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:transcriptionStartSite
|
chr1:164,788,000 (GRCh38)
|
|
gptkbp:UniProtID
|
P14859
|
|
gptkbp:bfsParent
|
gptkb:POU_family
|
|
gptkbp:bfsLayer
|
7
|