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gptkbp:instanceOf
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UniProt accession number
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gptkbp:alternativeName
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gptkb:Organic_cation_transporter_1
gptkb:OCT1
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gptkbp:associatedWith
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gptkb:Morphine
gptkb:Metformin
gptkb:Ondansetron
gptkb:Imatinib
Metformin response
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gptkbp:biologicalProcess
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organic cation transport
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gptkbp:cellularComponent
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gptkb:plasma_membrane
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gptkbp:clinicalVariant
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rs622342
rs628031
rs72552763
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gptkbp:database
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gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:HGNC
gptkb:UniProt
gptkb:Ensembl
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gptkbp:Entrez_Gene_ID
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gptkb:ENSG00000183023
6580
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gptkbp:expressedIn
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Highly expressed in liver
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gptkbp:firstDescribed
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1997
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gptkbp:function
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Mediates uptake of organic cations in the liver
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gptkbp:gene
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gptkb:SLC22A1
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gptkbp:goMolecularFunction
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organic cation transmembrane transporter activity
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gptkbp:hasIsoform
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2 isoforms described
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gptkbp:hasPolymorphism
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Affects drug response
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gptkbp:hgncID
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11056
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https://www.w3.org/2000/01/rdf-schema#label
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O00750
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gptkbp:length
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554 amino acids
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gptkbp:locatedOnChromosome
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6
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gptkbp:location
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6q25.3
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gptkbp:molecularWeight
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61.4 kDa
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gptkbp:mutationAssociatedWith
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Alters metformin pharmacokinetics
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:orthologIn
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Mouse Slc22a1
Rat Slc22a1
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gptkbp:pathway
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Drug metabolism
Xenobiotic transport
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gptkbp:pharmaceuticalRelevance
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Drug transporter
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gptkbp:protein_name
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Solute carrier family 22 member 1
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gptkbp:refersTo
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Human protein SLC22A1
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gptkbp:RefSeq
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NP_003042.2
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gptkbp:reviewedBy
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gptkb:UniProtKB/Swiss-Prot
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gptkbp:sequenceStatus
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Reviewed
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gptkbp:structure
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Multi-pass membrane protein
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gptkbp:subcellularLocation
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Plasma membrane
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gptkbp:tissue_specificity
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Liver, kidney, intestine
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gptkbp:transmembraneDomains
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12
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gptkbp:transporterFamily
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gptkb:SLC22
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gptkbp:UniProt_entry_name
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S22A1_HUMAN
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gptkbp:bfsParent
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gptkb:PIK3C2B
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gptkbp:bfsLayer
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6
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