Nucleoside Reverse Transcriptase Inhibitors

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:antiretroviral_drug_class
gptkbp:abbreviation	gptkb:NRTIs
gptkbp:administeredBy	oral route
gptkbp:category	gptkb:antiviral_drug
gptkbp:contraindication	severe liver disease
gptkbp:discoveredIn	1980s
gptkbp:example_drug	gptkb:tenofovir_disoproxil_fumarate gptkb:didanosine gptkb:stavudine gptkb:abacavir gptkb:lamivudine gptkb:zidovudine gptkb:tenofovir_alafenamide emtricitabine
gptkbp:excretion	kidneys
gptkbp:hasApprovedDrug	gptkb:zidovudine
gptkbp:includedIn	gptkb:HAART
gptkbp:mechanismOfAction	block viral DNA synthesis inhibit reverse transcriptase
gptkbp:metabolism	liver
gptkbp:pregnancyCategory	varies by drug
gptkbp:resistantTo	HIV reverse transcriptase mutations
gptkbp:sideEffect	gptkb:peripheral_neuropathy gptkb:anemia lactic acidosis hepatic steatosis
gptkbp:target	gptkb:HIV-1 gptkb:HIV-2
gptkbp:usedFor	HIV treatment
gptkbp:bfsParent	gptkb:NRTIs
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	Nucleoside Reverse Transcriptase Inhibitors