Nucleoside Reverse Transcriptase Inhibitors

URI: https://gptkb.org/entity/Nucleoside_Reverse_Transcriptase_Inhibitors
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:antiretroviral_drug_class
gptkbp:abbreviation gptkb:NRTIs
gptkbp:administeredBy oral route
gptkbp:category gptkb:antiviral_drug
gptkbp:contraindication severe liver disease
gptkbp:discoveredIn 1980s
gptkbp:example_drug gptkb:tenofovir_disoproxil_fumarate
gptkb:didanosine
gptkb:stavudine
gptkb:abacavir
gptkb:lamivudine
gptkb:zidovudine
gptkb:tenofovir_alafenamide
emtricitabine
gptkbp:excretion kidneys
gptkbp:hasApprovedDrug gptkb:zidovudine
gptkbp:includedIn gptkb:HAART
gptkbp:mechanismOfAction block viral DNA synthesis
inhibit reverse transcriptase
gptkbp:metabolism liver
gptkbp:pregnancyCategory varies by drug
gptkbp:resistantTo HIV reverse transcriptase mutations
gptkbp:sideEffect gptkb:peripheral_neuropathy
gptkb:anemia
lactic acidosis
hepatic steatosis
gptkbp:target gptkb:HIV-1
gptkb:HIV-2
gptkbp:usedFor HIV treatment
gptkbp:bfsParent gptkb:NRTIs
gptkbp:bfsLayer 6
https://www.w3.org/2000/01/rdf-schema#label Nucleoside Reverse Transcriptase Inhibitors