Statements (34)
Predicate | Object |
---|---|
gptkbp:instanceOf |
antiviral drug
protease inhibitor |
gptkbp:approvalYear |
1995
|
gptkbp:approvedBy |
gptkb:FDA
|
gptkbp:ATCCode |
gptkb:J05AF05
|
gptkbp:bioavailability |
80–87%
|
gptkbp:brand |
gptkb:Combivir
gptkb:Epivir gptkb:Epivir-HBV gptkb:Kivexa gptkb:Trizivir |
gptkbp:CASNumber |
gptkb:134678-17-4
|
gptkbp:developedBy |
GlaxoSmithKline
|
gptkbp:eliminationHalfLife |
5–7 hours
|
gptkbp:excretion |
renal
|
gptkbp:hasMolecularFormula |
gptkb:C8H11N3O3S
|
https://www.w3.org/2000/01/rdf-schema#label |
lamivudine
|
gptkbp:legalStatus |
prescription only
|
gptkbp:mechanismOfAction |
inhibits reverse transcriptase
|
gptkbp:metabolism |
minimal
|
gptkbp:pregnancyCategory |
C (US)
B3 (Australia) |
gptkbp:proteinBinding |
<36%
|
gptkbp:routeOfAdministration |
oral
|
gptkbp:sideEffect |
nausea
diarrhea fatigue headache |
gptkbp:usedFor |
HIV infection
chronic hepatitis B |
gptkbp:WHOModelListOfEssentialMedicines |
yes
|
gptkbp:bfsParent |
gptkb:NRTIs
gptkb:Hepatitis_B |
gptkbp:bfsLayer |
5
|