gptkbp:instance_of
|
gptkb:immunotherapy
|
gptkbp:administered_by
|
oral tablet
|
gptkbp:approves
|
gptkb:FDA
|
gptkbp:atccode
|
J05 AF03
|
gptkbp:available_on
|
generic drug
|
gptkbp:brand
|
Zerit
|
gptkbp:casnumber
|
30516-87-1
|
gptkbp:chemical_formula
|
C10 H12 N2 O4
|
gptkbp:clinical_trial
|
Phase II
Phase III
|
gptkbp:clinical_use
|
HIV treatment regimen
|
gptkbp:composed_by
|
gptkb:chemical_compound
|
gptkbp:contraindication
|
severe liver disease
pancreatitis
hypersensitivity to stavudine
|
gptkbp:developed_by
|
gptkb:Bristol-Myers_Squibb
|
gptkbp:discovered_by
|
gptkb:1980s
|
gptkbp:drug_interactions
|
gptkb:didanosine
gptkb:lamivudine
gptkb:zidovudine
|
gptkbp:formulation
|
gptkb:capsule
suspension
|
https://www.w3.org/2000/01/rdf-schema#label
|
stavudine
|
gptkbp:invention
|
gptkb:2001
patented
|
gptkbp:lifespan
|
1.5 hours
|
gptkbp:marketed_as
|
Zerit
|
gptkbp:mechanism_of_action
|
gptkb:nucleoside_reverse_transcriptase_inhibitor
|
gptkbp:metabolism
|
liver
|
gptkbp:pharmacokinetics
|
oral bioavailability 86%
|
gptkbp:second_line_treatment
|
HIV infection
|
gptkbp:side_effect
|
gptkb:lipodystrophy
fatigue
headache
nausea
diarrhea
lactic acidosis
neuropathy
|
gptkbp:treatment
|
HIV infection
|
gptkbp:used_for
|
treatment of HIV/ AIDS
|
gptkbp:whoessential_medicines
|
yes
|
gptkbp:bfsParent
|
gptkb:azidothymidine_(AZT)
|
gptkbp:bfsLayer
|
5
|