|
gptkbp:instanceOf
|
gptkb:protein
growth factor
|
|
gptkbp:alternativeName
|
gptkb:NT-3
gptkb:NTF3
|
|
gptkbp:binds
|
gptkb:p75NTR_receptor
gptkb:TrkC_receptor
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodedBy
|
gptkb:NTF3_gene
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
brain
heart
liver
pancreas
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
promotes survival and differentiation of neurons
|
|
gptkbp:HGNC_ID
|
8020
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Neurotrophin-3
|
|
gptkbp:length
|
257 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12p13
|
|
gptkbp:memberOf
|
neurotrophin family
|
|
gptkbp:molecularWeight
|
29 kDa
|
|
gptkbp:OMIM
|
162580
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:postTranslationalModification
|
glycosylation
disulfide bond formation
|
|
gptkbp:RefSeq
|
NP_002518.1
|
|
gptkbp:relatedTo
|
gptkb:nerve_growth_factor
gptkb:brain-derived_neurotrophic_factor
gptkb:neurotrophin-4
|
|
gptkbp:role
|
gptkb:synaptic_plasticity
axon growth
dendrite growth
neuronal survival
development of peripheral nervous system
development of central nervous system
|
|
gptkbp:significance
|
implicated in neurodevelopmental disorders
implicated in neurodegenerative diseases
implicated in hearing loss
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:UniProtID
|
P20783
|
|
gptkbp:bfsParent
|
gptkb:NT-3
|
|
gptkbp:bfsLayer
|
7
|