Neuropilin-1

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:CD304
NP-1
BDCA-4
VEGF165R
gptkbp:alternativeSplicing produces multiple isoforms
gptkbp:associatedWith cancer progression
immune response
SARS-CoV-2 entry
gptkbp:binds gptkb:VEGF-A
semaphorins
gptkbp:discoveredBy Fujisawa et al.
gptkbp:encodedBy gptkb:NRP1_gene
gptkbp:expressedIn neurons
endothelial cells
immune cells
gptkbp:firstDescribed 1992
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function cell surface receptor
mediates cell signaling
involved in axon guidance
involved in angiogenesis
gptkbp:gene gptkb:NRP1
gptkbp:GO_term GO:0015026
https://www.w3.org/2000/01/rdf-schema#label Neuropilin-1
gptkbp:interactsWith gptkb:VEGFR2
plexins
gptkbp:locatedOnChromosome 10p12
gptkbp:location gptkb:cell_membrane
gptkbp:molecularWeight ~130 kDa
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 2QQK
gptkbp:postTranslationalModification phosphorylation
glycosylation
gptkbp:reviewedBy gptkb:science
gptkb:Nature_Reviews_Cancer
Cell
gptkbp:role gptkb:COVID-19
autoimmune diseases
diabetic retinopathy
nervous system development
tumor metastasis
vascular development
gptkbp:structure single-pass type I membrane protein
gptkbp:target therapeutic antibodies
small molecule inhibitors
gptkbp:UniProtID O14786
gptkbp:bfsParent gptkb:NRP1
gptkbp:bfsLayer 6