|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD304
NP-1
BDCA-4
VEGF165R
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:immune_response
cancer progression
SARS-CoV-2 entry
|
|
gptkbp:binds
|
gptkb:VEGF-A
semaphorins
|
|
gptkbp:discoveredBy
|
Fujisawa et al.
|
|
gptkbp:encodedBy
|
gptkb:NRP1_gene
|
|
gptkbp:expressedIn
|
gptkb:neurons
endothelial cells
immune cells
|
|
gptkbp:firstDescribed
|
1992
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:cell_surface_receptor
mediates cell signaling
involved in axon guidance
involved in angiogenesis
|
|
gptkbp:gene
|
gptkb:NRP1
|
|
gptkbp:GO_term
|
GO:0015026
|
|
gptkbp:interactsWith
|
gptkb:VEGFR2
plexins
|
|
gptkbp:locatedOnChromosome
|
10p12
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
~130 kDa
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2QQK
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:reviewedBy
|
gptkb:science
gptkb:Nature_Reviews_Cancer
gptkb:Cell
|
|
gptkbp:role
|
gptkb:COVID-19
autoimmune diseases
diabetic retinopathy
nervous system development
tumor metastasis
vascular development
|
|
gptkbp:structure
|
single-pass type I membrane protein
|
|
gptkbp:target
|
therapeutic antibodies
small molecule inhibitors
|
|
gptkbp:UniProtID
|
O14786
|
|
gptkbp:bfsParent
|
gptkb:NRP1
gptkb:NRP-1
gptkb:CD304
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Neuropilin-1
|