|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:contraindication
|
gptkb:peptic_ulcer_disease
chronic kidney disease
aspirin allergy
|
|
gptkbp:discoveredIn
|
20th century
|
|
gptkbp:drugInteraction
|
gptkb:methotrexate
lithium
ACE inhibitors
diuretics
anticoagulants
|
|
gptkbp:example
|
gptkb:diclofenac
gptkb:ibuprofen
gptkb:naproxen
gptkb:aspirin
gptkb:celecoxib
indomethacin
|
|
gptkbp:introducedIn
|
aspirin in 1899
|
|
gptkbp:mechanismOfAction
|
reduces prostaglandin synthesis
inhibits cyclooxygenase enzymes
|
|
gptkbp:notableFor
|
gptkb:analgesic
gptkb:antipyretic
anti-inflammatory
non-opioid
|
|
gptkbp:notEffectiveAgainst
|
viral infections
bacterial infections
|
|
gptkbp:overdoseSymptoms
|
gptkb:acute_kidney_injury
coma
seizures
metabolic acidosis
|
|
gptkbp:pregnancyCategory
|
varies by drug
|
|
gptkbp:regulates
|
prescription and over-the-counter
|
|
gptkbp:riskFactor
|
hypertension
gastrointestinal bleeding
cardiovascular events
renal toxicity
|
|
gptkbp:routeOfAdministration
|
oral
topical
intravenous
|
|
gptkbp:sideEffect
|
renal impairment
increased bleeding risk
gastrointestinal irritation
ulcer formation
|
|
gptkbp:standsFor
|
gptkb:nonsteroidal_anti-inflammatory_drug
|
|
gptkbp:usedFor
|
pain relief
fever reduction
inflammation reduction
|
|
gptkbp:bfsParent
|
gptkb:Motrin
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NSAID
|