Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
|
| gptkbp:contraindication |
gptkb:peptic_ulcer_disease
chronic kidney disease aspirin allergy |
| gptkbp:discoveredIn |
20th century
|
| gptkbp:drugInteraction |
gptkb:methotrexate
lithium ACE inhibitors diuretics anticoagulants |
| gptkbp:example |
gptkb:diclofenac
gptkb:ibuprofen gptkb:naproxen gptkb:aspirin gptkb:celecoxib indomethacin |
| https://www.w3.org/2000/01/rdf-schema#label |
NSAID
|
| gptkbp:introducedIn |
aspirin in 1899
|
| gptkbp:mechanismOfAction |
reduces prostaglandin synthesis
inhibits cyclooxygenase enzymes |
| gptkbp:notableFor |
analgesic
anti-inflammatory antipyretic non-opioid |
| gptkbp:notEffectiveAgainst |
viral infections
bacterial infections |
| gptkbp:overdoseSymptoms |
coma
seizures metabolic acidosis acute kidney injury |
| gptkbp:pregnancyCategory |
varies by drug
|
| gptkbp:regulates |
prescription and over-the-counter
|
| gptkbp:riskFactor |
hypertension
gastrointestinal bleeding cardiovascular events renal toxicity |
| gptkbp:routeOfAdministration |
oral
topical intravenous |
| gptkbp:sideEffect |
renal impairment
increased bleeding risk gastrointestinal irritation ulcer formation |
| gptkbp:standsFor |
nonsteroidal anti-inflammatory drug
|
| gptkbp:usedFor |
pain relief
fever reduction inflammation reduction |
| gptkbp:bfsParent |
gptkb:Motrin
gptkb:Voltaren |
| gptkbp:bfsLayer |
5
|