|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:ionotropic_glutamate_receptor
|
|
gptkbp:activatedBy
|
gptkb:N-methyl-D-aspartate
depolarization
glutamate binding
|
|
gptkbp:blockedIn
|
magnesium ions
|
|
gptkbp:co-agonist
|
glycine
|
|
gptkbp:discoveredBy
|
gptkb:Richard_Evans
gptkb:Jeff_Watkins
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:Alzheimer's_disease
epilepsy
schizophrenia
stroke
neurotoxicity
|
|
gptkbp:enemyOf
|
gptkb:memantine
gptkb:ketamine
gptkb:phencyclidine
gptkb:dizocilpine
gptkb:APV
|
|
gptkbp:foundIn
|
brain
central nervous system
|
|
gptkbp:function
|
mediate excitatory neurotransmission
mediate synaptic plasticity
|
|
gptkbp:gene
|
gptkb:GRIN1
gptkb:GRIN2A
gptkb:GRIN2B
gptkb:GRIN2C
gptkb:GRIN2D
gptkb:GRIN3A
gptkb:GRIN3B
|
|
gptkbp:inhibitedBy
|
ethanol
nitrous oxide
volatile anesthetics
|
|
gptkbp:ligand
|
glutamate
glycine
|
|
gptkbp:location
|
postsynaptic membrane
|
|
gptkbp:modulatedBy
|
gptkb:protons
zinc
neurosteroids
polyamines
redox agents
|
|
gptkbp:namedAfter
|
gptkb:N-methyl-D-aspartate
|
|
gptkbp:permeableTo
|
calcium ions
potassium ions
sodium ions
|
|
gptkbp:role
|
gptkb:long-term_potentiation
memory
learning
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:subunit
|
gptkb:NR2A
gptkb:NR2B
gptkb:NR2C
gptkb:NR2D
gptkb:NR3A
gptkb:NR3B
NR1
|
|
gptkbp:type
|
gptkb:voltage-gated_potassium_channel
|
|
gptkbp:bfsParent
|
gptkb:place_cells
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NMDA receptors
|