|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:GRIN2B
GluN2B
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:autism_spectrum_disorder
neurodevelopmental disorders
|
|
gptkbp:component
|
gptkb:NMDA_receptor
|
|
gptkbp:downregulatedDuring
|
adulthood
|
|
gptkbp:encodedBy
|
GRIN2B gene
|
|
gptkbp:enemyOf
|
glutamate
glycine
Ro 25-6981
ifenprodil
|
|
gptkbp:Entrez_Gene_ID
|
2904
ENSG00000183454
|
|
gptkbp:expressedIn
|
early postnatal development
|
|
gptkbp:foundIn
|
central nervous system
|
|
gptkbp:function
|
modulates synaptic plasticity
involved in learning and memory
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NR2B
|
|
gptkbp:interactsWith
|
gptkb:PSD-95
NR1 subunit
|
|
gptkbp:locatedOnChromosome
|
chromosome 12p13.1
|
|
gptkbp:molecularWeight
|
~180 kDa
|
|
gptkbp:mutationAssociatedWith
|
epilepsy
intellectual disability
|
|
gptkbp:phosphorylates
|
tyrosine 1472
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
transmembrane protein
|
|
gptkbp:UniProtID
|
Q13224
|
|
gptkbp:bfsParent
|
gptkb:NR2
gptkb:NMDA_receptor
gptkb:NMDA_receptors
|
|
gptkbp:bfsLayer
|
7
|