NGF (nerve growth factor)

URI: https://gptkb.org/entity/NGF_(nerve_growth_factor)
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
growth factor
gptkbp:abbreviation gptkb:NGF
gptkbp:alternativeName gptkb:NGFB
gptkb:beta-NGF
gptkbp:associatedWith gptkb:Alzheimer's_disease
pain
peripheral neuropathy
gptkbp:category signaling molecule
neurotrophin
gptkbp:discoveredBy gptkb:Rita_Levi-Montalcini
gptkb:Stanley_Cohen
gptkbp:discoveredIn 1950s
gptkbp:EC_number none
gptkbp:Entrez_Gene_ID ENSG00000134259
gptkbp:fullName gptkb:nerve_growth_factor
gptkbp:function gptkb:neurotrophin_TRK_receptor_signaling_pathway
gptkb:positive_regulation_of_neuron_differentiation
promotes survival and differentiation of neurons
regulates growth, maintenance, and survival of nerve cells
positive regulation of cell survival
gptkbp:gene gptkb:NGF
gptkbp:HGNC_ID 7808
https://www.w3.org/2000/01/rdf-schema#label NGF (nerve growth factor)
gptkbp:locatedOnChromosome 1p13.1 (human)
gptkbp:molecularWeight 26 kDa (homodimer)
gptkbp:NobelPrizeYear Rita Levi-Montalcini and Stanley Cohen, 1986, Physiology or Medicine
gptkbp:OMIM 162030
gptkbp:organism gptkb:human
gptkb:mouse
right
gptkbp:PDB gptkb:1BET
gptkb:1SGF
gptkbp:predecessor proNGF
gptkbp:proteinFamily neurotrophin family
gptkbp:recipient gptkb:TrkA
gptkb:p75NTR
gptkbp:RefSeq NM_002506
gptkbp:sequence polypeptide
gptkbp:structure homodimer
gptkbp:tissue_specificity gptkb:adrenal_gland
gptkb:prostate
gptkb:testis
brain
heart
salivary gland
immune cells
gptkbp:UniGene Hs.654497
gptkbp:UniProtID gptkb:P01138
gptkbp:bfsParent gptkb:Neurotrophin_signaling_pathway
gptkbp:bfsLayer 8