|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:protein_kinase_C
phagocytosis
|
|
gptkbp:activity
|
cytochrome c reduction
lucigenin chemiluminescence
|
|
gptkbp:catalyzes
|
reduction of oxygen to superoxide
|
|
gptkbp:component
|
gptkb:gp91phox
p22phox
p40phox
p67phox
Rac GTPase
p47phox
|
|
gptkbp:deficiencyCauses
|
gptkb:chronic_granulomatous_disease
|
|
gptkbp:discoveredBy
|
Bernard Babior
|
|
gptkbp:EC_number
|
1.6.3.1
|
|
gptkbp:expressedIn
|
gptkb:microglia
macrophages
endothelial cells
neutrophils
|
|
gptkbp:firstDescribed
|
1978
|
|
gptkbp:foundIn
|
phagocytes
|
|
gptkbp:function
|
produces reactive oxygen species
|
|
gptkbp:gene
|
gptkb:CYBA
gptkb:NCF1
gptkb:NCF2
gptkb:NCF4
gptkb:CYBB
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NADPH oxidase
|
|
gptkbp:inhibitedBy
|
gptkb:DPI
apocynin
|
|
gptkbp:location
|
gptkb:plasma_membrane
phagosomal membrane
|
|
gptkbp:molecularWeight
|
~450 kDa
|
|
gptkbp:orthologIn
|
gptkb:NOX2
DUOX1
DUOX2
NOX1
NOX3
NOX4
NOX5
|
|
gptkbp:product
|
gptkb:superoxide_anion
|
|
gptkbp:relatedTo
|
oxidative burst
respiratory burst
|
|
gptkbp:role
|
gptkb:cancer
gptkb:cardiovascular_disease
inflammation
neurodegeneration
innate immune response
host defense
|
|
gptkbp:substrate
|
gptkb:O2
NADPH
|
|
gptkbp:bfsParent
|
gptkb:Rac1
gptkb:superoxide_anion
|
|
gptkbp:bfsLayer
|
7
|