NADH:ubiquinone oxidoreductase (complex I)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alsoKnownAs	gptkb:Complex_I NADH dehydrogenase
gptkbp:cofactor	gptkb:FMN iron-sulfur clusters
gptkbp:compatibleWith	archaea
gptkbp:component	oxidative phosphorylation electron transport chain
gptkbp:discoveredBy	Ernst Stäcker (partial discovery, 1960s)
gptkbp:EC_number	1.6.5.3
gptkbp:firstComplexOf	mitochondrial respiratory chain
gptkbp:foundIn	gptkb:Bacteria eukaryotes
gptkbp:function	catalyzes electron transfer from NADH to ubiquinone pumps protons across mitochondrial inner membrane
gptkbp:gene	gptkb:mitochondrial_DNA nuclear DNA
https://www.w3.org/2000/01/rdf-schema#label	NADH:ubiquinone oxidoreductase (complex I)
gptkbp:inhibitedBy	gptkb:piericidin_A gptkb:rotenone amytal
gptkbp:locatedIn	mitochondrial inner membrane
gptkbp:molecularWeight	~980 kDa (human)
gptkbp:mutationAssociatedWith	gptkb:Leigh_syndrome mitochondrial diseases
gptkbp:orthologIn	bacterial NDH-1 complex
gptkbp:presentIn	gptkb:protists animals fungi plants some bacteria
gptkbp:product	gptkb:ubiquinol NAD+ protons (H+)
gptkbp:requires	ATP production
gptkbp:role	energy metabolism cellular respiration reduction of ubiquinone generation of proton gradient oxidation of NADH
gptkbp:structure	L-shaped
gptkbp:substrate	gptkb:NADH ubiquinone
gptkbp:subunit	gptkb:ND1 gptkb:ND2 gptkb:NDUFS1 gptkb:NDUFS2 gptkb:NDUFV1
gptkbp:subunitCount	at least 45
gptkbp:systematicName	gptkb:NADH:ubiquinone_oxidoreductase
gptkbp:bfsParent	gptkb:EC_7.1.1.9
gptkbp:bfsLayer	7