Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alsoKnownAs |
gptkb:NADH:ubiquinone_oxidoreductase
NADH dehydrogenase (ubiquinone) |
| gptkbp:assemblyRequires |
chaperone proteins
assembly factors |
| gptkbp:contains |
gptkb:FMN
iron-sulfur clusters |
| gptkbp:determines |
X-ray crystallography
cryo-electron microscopy |
| gptkbp:EC_number |
1.6.5.3
|
| gptkbp:firstDescribed |
1960s
|
| gptkbp:foundIn |
eukaryotes
some bacteria |
| gptkbp:function |
catalyzes transfer of electrons from NADH to ubiquinone
pumps protons across mitochondrial membrane |
| gptkbp:gene |
gptkb:mitochondrial_DNA
nuclear DNA |
| gptkbp:hasSubcomplex |
N-module
P-module Q-module |
| https://www.w3.org/2000/01/rdf-schema#label |
Complex I
|
| gptkbp:inhibitedBy |
gptkb:piericidin_A
gptkb:rotenone amytal |
| gptkbp:involvedIn |
neurodegenerative diseases
apoptosis regulation |
| gptkbp:locatedIn |
inner mitochondrial membrane
|
| gptkbp:malfunctionLeadsTo |
reduced ATP production
increased reactive oxygen species |
| gptkbp:molecularWeight |
~980 kDa in mammals
|
| gptkbp:mutationAssociatedWith |
gptkb:Leigh_syndrome
mitochondrial diseases Parkinson's disease (implicated) |
| gptkbp:orthologIn |
bacterial NDH-1 complex
|
| gptkbp:partOf |
electron transport chain
|
| gptkbp:product |
gptkb:ubiquinol
NAD+ proton gradient |
| gptkbp:requires |
cellular respiration
|
| gptkbp:role |
oxidative phosphorylation
ATP synthesis |
| gptkbp:studiedIn |
model organisms (e.g., yeast, mouse, human)
|
| gptkbp:substrate |
gptkb:NADH
ubiquinone |
| gptkbp:subunit |
at least 45 protein subunits in mammals
|
| gptkbp:target |
some pesticides
mitochondrial toxins |
| gptkbp:bfsParent |
gptkb:NADH:ubiquinone_oxidoreductase
gptkb:ND2 gptkb:ND6 gptkb:NDUFS1 gptkb:NDUFV1 |
| gptkbp:bfsLayer |
7
|