Myb proto-oncogene protein

URI: https://gptkb.org/entity/Myb_proto-oncogene_protein
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeSplicing yes
gptkbp:associatedWith gptkb:cancer
gptkbp:biologicalProcess cell proliferation
oncogenesis
hematopoiesis
sequence-specific DNA binding
transcriptional activator activity
gptkbp:domain DNA-binding domain
gptkbp:encodedBy gptkb:MYB_gene
gptkbp:Entrez_Gene_ID 4602
gptkbp:expressedIn colon
hematopoietic cells
breast tissue
prostate tissue
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function transcription factor
gptkbp:HGNC_ID 7545
https://www.w3.org/2000/01/rdf-schema#label Myb proto-oncogene protein
gptkbp:interactsWith gptkb:CBP/p300
gptkb:CREB-binding_protein
gptkb:Cyclin_D1
gptkbp:involvedIn apoptosis
cell differentiation
cell cycle regulation
gptkbp:length 640 amino acids
gptkbp:locatedOnChromosome gptkb:6q23
gptkbp:molecularWeight 75 kDa
gptkbp:mutationAssociatedWith gptkb:cancer
gptkb:acute_myeloid_leukemia
gptkb:T-cell_acute_lymphoblastic_leukemia
colorectal cancer
adenoid cystic carcinoma
gptkbp:OMIM 189990
gptkbp:orthologIn gptkb:A-Myb
gptkb:B-Myb
c-Myb (chicken)
gptkbp:PDB gptkb:1MSE
gptkbp:postTranslationalModification phosphorylation
ubiquitination
acetylation
gptkbp:regulates gene expression
cellular proliferation
differentiation of hematopoietic cells
apoptosis in progenitor cells
gptkbp:subcellularLocation gptkb:nucleus
gptkbp:UniProtID P10242
gptkbp:bfsParent gptkb:Myb_protein
gptkbp:bfsLayer 8