Methylthioadenosine phosphorylase

URI: https://gptkb.org/entity/Methylthioadenosine_phosphorylase
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:MTAP
5'-methylthioadenosine phosphorylase
MTA phosphorylase
gptkbp:associatedWith gptkb:biliary_tract_cancer
gptkb:cancer
gptkb:glioblastoma
gptkb:T-cell_lymphoma
colorectal cancer
esophageal cancer
leukemia
melanoma
mesothelioma
pancreatic cancer
prostate cancer
bladder cancer
head and neck cancer
osteosarcoma
renal cell carcinoma
gptkbp:catalyzes phosphorolysis of 5'-methylthioadenosine
gptkbp:cofactor phosphate
gptkbp:deficiency_associated_with various cancers
gptkbp:EC_number 2.4.2.28
gptkbp:Enzyme_Commission_class gptkb:glycosyltransferase
gptkbp:expressedIn most human tissues
gptkbp:foundIn gptkb:yeast
gptkb:Bacteria
humans
gptkbp:gene gptkb:MTAP
gptkbp:gene_deletion common in some tumors
gptkbp:HGNC_ID 7408
https://www.w3.org/2000/01/rdf-schema#label Methylthioadenosine phosphorylase
gptkbp:inhibitedBy methylthioadenosine analogs
gptkbp:involves gptkb:methionine_salvage_pathway
gptkbp:locatedOnChromosome gptkb:9p21
gptkbp:molecularWeight 29 kDa
gptkbp:mutationAssociatedWith MTAP deficiency
gptkbp:OMIM 156540
gptkbp:pathway polyamine biosynthesis
gptkbp:product adenine
5-methylthioribose-1-phosphate
gptkbp:RefSeq gptkb:NM_002451
gptkbp:structure_available_in gptkb:Protein_Data_Bank
gptkbp:substrate 5'-methylthioadenosine
gptkbp:subunit homotrimer
gptkbp:UniProtID P30989 (human)
gptkbp:usedFor potential cancer therapy target
gptkbp:bfsParent gptkb:MTAP
gptkbp:bfsLayer 7