|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:antibiotic
|
|
gptkbp:approvedBy
|
1962
|
|
gptkbp:ATCCode
|
J01EA01
|
|
gptkbp:bioavailability
|
90-100%
|
|
gptkbp:brand
|
gptkb:Primsol
gptkb:Proloprim
gptkb:Trimpex
|
|
gptkbp:CASNumber
|
738-70-5
|
|
gptkbp:category
|
gptkb:antibiotic
antifolate
pyrimidine derivative
|
|
gptkbp:color
|
white to off-white
|
|
gptkbp:combines
|
sulfamethoxazole
|
|
gptkbp:contraindication
|
pregnancy
megaloblastic anemia
|
|
gptkbp:discoveredBy
|
gptkb:Gertrude_Elion
gptkb:George_Hitchings
|
|
gptkbp:discoveredIn
|
1962
|
|
gptkbp:eliminationHalfLife
|
8-10 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasMolecularFormula
|
C14H18N4O3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Trimethoprim
|
|
gptkbp:includedIn
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:IUPACName
|
5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
|
|
gptkbp:KEGGID
|
D00264
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
dihydrofolate reductase inhibitor
|
|
gptkbp:meltingPoint
|
199-200°C
|
|
gptkbp:MeSH_ID
|
gptkb:D014244
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
290.32 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
44%
|
|
gptkbp:PubChem_CID
|
5377
5578
CHEMBL40
DB00440
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
nausea
vomiting
itching
rash
hyperkalemia
|
|
gptkbp:solubility
|
0.4 mg/mL
|
|
gptkbp:UNII
|
9NZD839VMK
|
|
gptkbp:usedFor
|
gptkb:pneumocystis_pneumonia
urinary tract infection
respiratory tract infection
traveler's diarrhea
|
|
gptkbp:bfsParent
|
gptkb:TMP
|
|
gptkbp:bfsLayer
|
5
|