Metabotropic glutamate receptor

URI: https://gptkb.org/entity/Metabotropic_glutamate_receptor
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:G_protein-coupled_receptor
gptkbp:alternativeName mGluR
gptkbp:binds glutamate
gptkbp:discoveredIn 1990s
gptkbp:doesNotForm ion channel
gptkbp:encodedBy GRM genes
gptkbp:expressedIn neurons
glial cells
gptkbp:foundIn central nervous system
gptkbp:function regulation of neuronal excitability
modulation of synaptic transmission
gptkbp:groupIIIIncludes mGluR4
mGluR6
mGluR7
mGluR8
gptkbp:groupIIIncludes mGluR3
mGluR2
gptkbp:groupIIncludes mGluR1
mGluR5
https://www.w3.org/2000/01/rdf-schema#label Metabotropic glutamate receptor
gptkbp:involves gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:depression
epilepsy
schizophrenia
anxiety
gptkbp:modulatedBy learning and memory
neuronal plasticity
cAMP levels
second messenger systems
phospholipase C activity
gptkbp:orthologIn gptkb:mouse
gptkb:zebrafish
right
gptkbp:relatedGroup gptkb:Group_I
gptkb:Group_II
gptkb:Group_III
gptkbp:structure seven transmembrane domains
gptkbp:subclassOf gptkb:glutamate_receptor
gptkbp:subspecies mGluR3
mGluR1
mGluR2
mGluR4
mGluR5
mGluR6
mGluR7
mGluR8
gptkbp:target pharmacological agents
gptkbp:type G protein-coupled pathway
gptkbp:bfsParent gptkb:Glutamate
gptkbp:bfsLayer 6