Membrane metallo-endopeptidase

URI: https://gptkb.org/entity/Membrane_metallo-endopeptidase
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:neprilysin
neutral endopeptidase
gptkbp:cofactor zinc
gptkbp:EC_number 3.4.24.11
gptkbp:encodedBy MME gene
gptkbp:expressedIn gptkb:leukocytes
gptkb:cancer
gptkb:kidney
brain
intestine
gptkbp:family M13 family of peptidases
gptkbp:foundIn gptkb:plasma_membrane
gptkbp:function inactivates peptide hormones such as enkephalins, substance P, and atrial natriuretic peptide
cleaves peptides at the amino side of hydrophobic residues
gptkbp:GO_term GO:0004267
https://www.w3.org/2000/01/rdf-schema#label Membrane metallo-endopeptidase
gptkbp:inhibitedBy phosphoramidon
thiorphan
gptkbp:locatedOnChromosome human chromosome 3q25
gptkbp:molecularWeight approximately 90-100 kDa
gptkbp:OMIM 120520
gptkbp:significance implicated in Alzheimer's disease
implicated in hypertension
gptkbp:structure type II integral membrane protein
gptkbp:substrate gptkb:angiotensin_II
gptkb:bradykinin
gptkb:enkephalins
gptkb:substance_P
atrial natriuretic peptide
gptkbp:UniProtID P08473
gptkbp:bfsParent gptkb:MME
gptkbp:bfsLayer 6