|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:hMSH2
MutS homolog 2
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:component
|
nucleoplasm
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
MSH2 gene
|
|
gptkbp:formsComplexWith
|
MSH3 protein
MSH6 protein
|
|
gptkbp:formsMutSαComplexWith
|
MSH6 protein
|
|
gptkbp:formsMutSβComplexWith
|
MSH3 protein
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
DNA mismatch repair
mismatch repair
|
|
gptkbp:GOProcess
|
DNA repair
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MSH2 protein
|
|
gptkbp:interactsWith
|
gptkb:PMS2_protein
gptkb:MLH1_protein
|
|
gptkbp:locatedOnChromosome
|
chromosome 2p21
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
~100 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Lynch_syndrome
gptkb:hereditary_nonpolyposis_colorectal_cancer
|
|
gptkbp:OMIM
|
609309
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
|
|
gptkbp:PDB
|
2O8B
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:requires
|
genome stability
|
|
gptkbp:UniProtID
|
P43246
|
|
gptkbp:bfsParent
|
gptkb:DNA_mismatch_repair_protein_Msh2
gptkb:DNA_mismatch_repair_protein_Msh6
gptkb:PMS2_protein
gptkb:Exonuclease_1_protein
|
|
gptkbp:bfsLayer
|
7
|