MSA-P

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf neurodegenerative disease subtype
gptkbp:abbreviation gptkb:Multiple_System_Atrophy_-_Parkinsonian_type
gptkbp:affects gptkb:basal_ganglia
autonomic nervous system
gptkbp:associatedWith alpha-synuclein accumulation
oligodendroglial cytoplasmic inclusions
gptkbp:averageSurvivalAfterDiagnosis 6-10 years
gptkbp:characterizedBy autonomic dysfunction
parkinsonism
poor response to levodopa
gptkbp:commonAutonomicSymptoms gptkb:orthostatic_hypotension
erectile dysfunction
urinary incontinence
gptkbp:commonMisdiagnosis gptkb:Parkinson's_disease
gptkbp:commonMotorSymptoms bradykinesia
postural instability
rigidity
gptkbp:diagnosedBy clinical evaluation
MRI brain imaging
gptkbp:differentialDiagnosis gptkb:Parkinson's_disease
gptkb:corticobasal_degeneration
gptkb:progressive_supranuclear_palsy
gptkbp:distinctFrom gptkb:MSA-C
gptkb:Parkinson's_disease
gptkbp:firstDescribed 1960s
gptkbp:fullName gptkb:Multiple_System_Atrophy_-_Parkinsonian_type
gptkbp:geneticStudies rare
gptkbp:hasEpidemiology slightly more common in men
gptkbp:hasNoCure true
https://www.w3.org/2000/01/rdf-schema#label MSA-P
gptkbp:ICD-10_code G90.3
gptkbp:mortalityRate high
gptkbp:neuropathology gptkb:striatonigral_degeneration
glial cytoplasmic inclusions
gptkbp:onset typically after age 50
gptkbp:prevalence rare
gptkbp:prognosis poor
gptkbp:progression gptkb:fire
gptkbp:relatedTo gptkb:MSA-C
gptkbp:riskFactor unknown
gptkbp:subspecies gptkb:Multiple_System_Atrophy
gptkbp:symptom bradykinesia
postural instability
rigidity
autonomic failure
gptkbp:treatment physical therapy
symptomatic management
autonomic support
gptkbp:bfsParent gptkb:Multiple_System_Atrophy
gptkb:multiple_system_atrophy
gptkbp:bfsLayer 7