Multiple System Atrophy - Parkinsonian type

URI: https://gptkb.org/entity/Multiple_System_Atrophy_-_Parkinsonian_type
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:neurodegenerative_disease
gptkbp:abbreviation gptkb:MSA-P
gptkbp:affects gptkb:basal_ganglia
gptkb:cerebellum
autonomic nervous system
gptkbp:associatedWith gptkb:alpha-synuclein
gptkbp:cause gptkb:unknown
gptkbp:characterizedBy autonomic dysfunction
parkinsonism
poor response to levodopa
gptkbp:diagnosedBy clinical evaluation
MRI brain
gptkbp:differentialDiagnosis gptkb:Parkinson's_disease
gptkb:Progressive_Supranuclear_Palsy
Corticobasal degeneration
gptkbp:firstDescribed 1960s
gptkbp:gender slightly more common in men
gptkbp:hasEpidemiology rare
gptkbp:ICD-10_code G90.3
gptkbp:medianSurvival 6-10 years
gptkbp:MeSH_ID D020754
gptkbp:notableFeature poor response to dopaminergic therapy
early autonomic failure
rapid progression compared to Parkinson's disease
gptkbp:OMIM 146500
gptkbp:onset adult
50-60 years
gptkbp:pathology glial cytoplasmic inclusions
gptkbp:prevalence 3-5 per 100,000
gptkbp:prognosis poor
gptkbp:progression gptkb:fire
gptkbp:riskFactor gptkb:unknown
gptkbp:subspecies gptkb:Multiple_System_Atrophy
gptkbp:symptom gptkb:orthostatic_hypotension
bradykinesia
postural instability
erectile dysfunction
urinary incontinence
muscle rigidity
speech difficulties
swallowing difficulties
gptkbp:treatment physical therapy
symptomatic management
autonomic support
gptkbp:bfsParent gptkb:MSA-P
gptkbp:bfsLayer 8
https://www.w3.org/2000/01/rdf-schema#label Multiple System Atrophy - Parkinsonian type