Multiple System Atrophy - Parkinsonian type
GPTKB entity
Statements (47)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
neurodegenerative disease
|
| gptkbp:abbreviation |
gptkb:MSA-P
|
| gptkbp:affects |
gptkb:basal_ganglia
gptkb:cerebellum autonomic nervous system |
| gptkbp:associatedWith |
gptkb:alpha-synuclein
|
| gptkbp:cause |
unknown
|
| gptkbp:characterizedBy |
autonomic dysfunction
parkinsonism poor response to levodopa |
| gptkbp:diagnosedBy |
clinical evaluation
MRI brain |
| gptkbp:differentialDiagnosis |
gptkb:Parkinson's_disease
gptkb:Progressive_Supranuclear_Palsy Corticobasal degeneration |
| gptkbp:firstDescribed |
1960s
|
| gptkbp:gender |
slightly more common in men
|
| gptkbp:hasEpidemiology |
rare
|
| https://www.w3.org/2000/01/rdf-schema#label |
Multiple System Atrophy - Parkinsonian type
|
| gptkbp:ICD-10_code |
G90.3
|
| gptkbp:medianSurvival |
6-10 years
|
| gptkbp:MeSH_ID |
D020754
|
| gptkbp:notableFeature |
poor response to dopaminergic therapy
early autonomic failure rapid progression compared to Parkinson's disease |
| gptkbp:OMIM |
146500
|
| gptkbp:onset |
adult
50-60 years |
| gptkbp:pathology |
glial cytoplasmic inclusions
|
| gptkbp:prevalence |
3-5 per 100,000
|
| gptkbp:prognosis |
poor
|
| gptkbp:progression |
gptkb:fire
|
| gptkbp:riskFactor |
unknown
|
| gptkbp:subspecies |
gptkb:Multiple_System_Atrophy
|
| gptkbp:symptom |
gptkb:orthostatic_hypotension
bradykinesia postural instability erectile dysfunction urinary incontinence muscle rigidity speech difficulties swallowing difficulties |
| gptkbp:treatment |
physical therapy
symptomatic management autonomic support |
| gptkbp:bfsParent |
gptkb:MSA-P
|
| gptkbp:bfsLayer |
8
|