|
gptkbp:instanceOf
|
neurodegenerative disease
|
|
gptkbp:abbreviation
|
gptkb:MSA
|
|
gptkbp:affects
|
movement
autonomic nervous system
|
|
gptkbp:cause
|
unknown
|
|
gptkbp:diagnosedBy
|
clinical evaluation
MRI
autonomic testing
|
|
gptkbp:firstDescribed
|
1969
|
|
gptkbp:frequency
|
rare
|
|
gptkbp:gender
|
slightly more common in men
|
|
gptkbp:hasNoCure
|
true
|
|
gptkbp:hasOrphanetID
|
gptkb:ORPHA102
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Multiple System Atrophy
|
|
gptkbp:ICD-10_code
|
G90.3
|
|
gptkbp:inheritance
|
sporadic
|
|
gptkbp:medianSurvival
|
6 to 10 years
|
|
gptkbp:MeSH_ID
|
D020754
|
|
gptkbp:MSA-C
|
cerebellar type
|
|
gptkbp:MSA-P
|
parkinsonian type
|
|
gptkbp:notableContributor
|
gptkb:Graham_and_Oppenheimer
|
|
gptkbp:OMIM
|
146500
|
|
gptkbp:onset
|
adult
50s to 60s
|
|
gptkbp:pathology
|
alpha-synuclein accumulation
glial cytoplasmic inclusions
|
|
gptkbp:prevalence
|
3 to 5 per 100,000
|
|
gptkbp:prognosis
|
progressive
poor
|
|
gptkbp:relatedTo
|
gptkb:Shy-Drager_syndrome
gptkb:olivopontocerebellar_atrophy
gptkb:Parkinson's_disease
gptkb:striatonigral_degeneration
|
|
gptkbp:riskFactor
|
age over 50
|
|
gptkbp:subspecies
|
gptkb:MSA-C
gptkb:MSA-P
|
|
gptkbp:symptom
|
gptkb:orthostatic_hypotension
bradykinesia
tremor
autonomic dysfunction
erectile dysfunction
parkinsonism
urinary incontinence
muscle rigidity
cerebellar ataxia
|
|
gptkbp:treatment
|
physical therapy
symptomatic management
medications for blood pressure
medications for parkinsonism
|
|
gptkbp:bfsParent
|
gptkb:Atypical_Parkinsonian_Syndromes
|
|
gptkbp:bfsLayer
|
6
|