|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
H-2 complex (in mice)
HLA proteins (in humans)
|
|
gptkbp:associatedWith
|
autoimmune diseases
|
|
gptkbp:binds
|
peptide antigens
|
|
gptkbp:component
|
gptkb:adaptive_immune_system
|
|
gptkbp:discoveredBy
|
gptkb:Jean_Dausset
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:encodedBy
|
MHC genes
|
|
gptkbp:expressedIn
|
all nucleated cells (class I)
antigen-presenting cells (class II)
|
|
gptkbp:foundIn
|
vertebrates
|
|
gptkbp:fullName
|
Major Histocompatibility Complex proteins
|
|
gptkbp:function
|
antigen presentation
|
|
gptkbp:hasPolymorphism
|
high
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MHC proteins
|
|
gptkbp:importantFor
|
immune surveillance
pathogen recognition
|
|
gptkbp:interactsWith
|
gptkb:CD4+_T_cells
gptkb:CD8+_T_cells
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6_(human)
|
|
gptkbp:location
|
cell surface
|
|
gptkbp:notExpressedOn
|
red blood cells
|
|
gptkbp:presentPeptidesFrom
|
intracellular proteins
extracellular proteins
|
|
gptkbp:recognizedBy
|
gptkb:T_cell_receptors
|
|
gptkbp:requires
|
self/non-self recognition
|
|
gptkbp:role
|
immune response
transplant rejection
|
|
gptkbp:species
|
high
|
|
gptkbp:structure
|
heterodimer
|
|
gptkbp:type
|
gptkb:MHC_class_II
gptkb:MHC_class_I
gptkb:MHC_class_III
|
|
gptkbp:usedIn
|
organ transplantation
tissue typing
|
|
gptkbp:variant
|
autoimmunity
allergic reactions
vaccine response
disease susceptibility
|
|
gptkbp:bfsParent
|
gptkb:MHC_complex
|
|
gptkbp:bfsLayer
|
7
|