|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
type I interferon response
|
|
gptkbp:alternativeName
|
gptkb:IFIH1_protein
gptkb:RH116
|
|
gptkbp:associatedWith
|
gptkb:Aicardi-Goutières_syndrome
gptkb:Singleton-Merten_syndrome
autoimmune diseases
|
|
gptkbp:discoveredBy
|
Yoshihiro Fujita et al.
|
|
gptkbp:discoveredIn
|
2002
|
|
gptkbp:encodedBy
|
gptkb:IFIH1_gene
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Melanoma_Differentiation-Associated_protein_5
|
|
gptkbp:function
|
cytoplasmic pattern recognition receptor
innate immune sensor
|
|
gptkbp:gene
|
gptkb:IFIH1
|
|
gptkbp:HGNC_ID
|
18873
|
|
gptkbp:homologInRat
|
gptkb:Ifih1
|
|
gptkbp:homologInZebrafish
|
gptkb:ifiH1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MDA5
|
|
gptkbp:interactsWith
|
gptkb:MAVS
|
|
gptkbp:involvedIn
|
apoptosis
regulation of immune response
antiviral response
inflammatory signaling
|
|
gptkbp:locale
|
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:2q24.2
|
|
gptkbp:mutationAssociatedWith
|
gptkb:systemic_lupus_erythematosus
gptkb:encephalopathy
asthma
type 1 diabetes
psoriasis
interstitial lung disease
inflammatory bowel disease
vitiligo
myositis
|
|
gptkbp:OMIM
|
606951
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ifih1
|
|
gptkbp:PDB
|
gptkb:4GL2
|
|
gptkbp:recognizedBy
|
viral double-stranded RNA
|
|
gptkbp:reviewedBy
|
gptkb:Journal_of_Immunology
gptkb:Nature_Immunology
gptkb:Cell_Host_&_Microbe
|
|
gptkbp:structure
|
contains CARD domains
contains DExD/H-box helicase domain
|
|
gptkbp:UniProtID
|
gptkb:Q9BYX4
|
|
gptkbp:bfsParent
|
gptkb:LGP2
|
|
gptkbp:bfsLayer
|
7
|