|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:abbreviation
|
gptkb:MAO-B
|
|
gptkbp:activeSiteResidue
|
gptkb:tyrosine
|
|
gptkbp:alternativeName
|
gptkb:MAO-B
gptkb:MAOB
amine oxidase B
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
|
|
gptkbp:catalyzes
|
oxidative deamination of monoamines
|
|
gptkbp:cofactor
|
gptkb:FAD
|
|
gptkbp:discoveredBy
|
gptkb:Mary_Bernheim
|
|
gptkbp:discoveredIn
|
1928
|
|
gptkbp:EC_number
|
1.4.3.4
|
|
gptkbp:Enzyme_Commission_family
|
oxidoreductase
|
|
gptkbp:expressedIn
|
brain
liver
platelets
|
|
gptkbp:foundIn
|
mitochondria
|
|
gptkbp:gene
|
gptkb:MAOB
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6833
|
|
gptkbp:homologous_to
|
gptkb:Monoamine_oxidase_A
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Monoamine oxidase B
|
|
gptkbp:inhibitedBy
|
gptkb:rasagiline
gptkb:selegiline
gptkb:safinamide
treatment of depression
treatment of Alzheimer's disease
treatment of Parkinson's disease
|
|
gptkbp:locatedOnChromosome
|
Xp11.3
|
|
gptkbp:location
|
outer mitochondrial membrane
|
|
gptkbp:molecularWeight
|
~58 kDa
|
|
gptkbp:OMIM
|
309860
|
|
gptkbp:PDB
|
gptkb:1GOS
|
|
gptkbp:produces
|
hydrogen peroxide
ammonia
aldehyde
|
|
gptkbp:role
|
dopamine metabolism
neurotransmitter catabolism
|
|
gptkbp:structure
|
dimer
|
|
gptkbp:substrate
|
gptkb:benzylamine
dopamine
phenylethylamine
|
|
gptkbp:type
|
reversible
irreversible
|
|
gptkbp:UniProtID
|
gptkb:P27338
|
|
gptkbp:bfsParent
|
gptkb:MAO-B
|
|
gptkbp:bfsLayer
|
7
|