|
gptkbp:instanceOf
|
mole
endotoxin
|
|
gptkbp:abbreviation
|
gptkb:LPS
|
|
gptkbp:analyzes
|
gptkb:SDS-PAGE
mass spectrometry
|
|
gptkbp:canBeNeutralizedBy
|
gptkb:polymyxin_B
|
|
gptkbp:canExtract
|
phenol-water extraction
|
|
gptkbp:cause
|
fever
septic shock
inflammation
hypotension
disseminated intravascular coagulation
|
|
gptkbp:component
|
cell envelope
|
|
gptkbp:composedOf
|
gptkb:lipid_A
O-antigen
core oligosaccharide
|
|
gptkbp:detects
|
Limulus amebocyte lysate assay
|
|
gptkbp:determines
|
X-ray crystallography
|
|
gptkbp:discoveredBy
|
gptkb:Richard_Pfeiffer
|
|
gptkbp:foundIn
|
outer membrane of Gram-negative bacteria
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Lipopolysaccharide
|
|
gptkbp:importantFor
|
bacterial virulence
bacterial structural integrity
|
|
gptkbp:inducedBy
|
strong immune response
|
|
gptkbp:isNotFoundIn
|
Gram-positive bacteria
|
|
gptkbp:isPyrogenic
|
true
|
|
gptkbp:isSolubleIn
|
gptkb:water
|
|
gptkbp:molecularWeight
|
10-20 kDa (varies)
|
|
gptkbp:presentIn
|
gptkb:Salmonella
gptkb:Neisseria_meningitidis
gptkb:Vibrio_cholerae
gptkb:Pseudomonas_aeruginosa
gptkb:Bacteria
|
|
gptkbp:promotion
|
dendritic cells
macrophages
cytokine production
monocytes
|
|
gptkbp:recognizedBy
|
gptkb:Toll-like_receptor_4
|
|
gptkbp:target
|
antibodies
bacteriophages
host immune system
|
|
gptkbp:thermalStability
|
true
|
|
gptkbp:toxicity
|
mammals
|
|
gptkbp:usedAs
|
adjuvant in research
|
|
gptkbp:usedIn
|
pyrogen testing
|
|
gptkbp:bfsParent
|
gptkb:E._coli
|
|
gptkbp:bfsLayer
|
6
|