|
gptkbp:instanceOf
|
gptkb:antibiotic
cyclic polypeptide
|
|
gptkbp:administeredBy
|
gptkb:pneumonia
meningitis
septicemia
skin infections
ear infections
urinary tract infections
eye infections
|
|
gptkbp:ATCCode
|
J01XB02
|
|
gptkbp:brand
|
Aerosporin
Poly-Rx
Polysporin
|
|
gptkbp:CASNumber
|
1405-20-5
|
|
gptkbp:chemicalFormula
|
C56H98N16O13
|
|
gptkbp:combines
|
gptkb:bacitracin
gptkb:neomycin
hydrocortisone
|
|
gptkbp:contraindication
|
gptkb:myasthenia_gravis
|
|
gptkbp:discoveredBy
|
A. M. Dubos
|
|
gptkbp:discoveredIn
|
1947
|
|
gptkbp:eliminationHalfLife
|
6 hours
|
|
gptkbp:excretion
|
renal
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
polymyxin B
|
|
gptkbp:includedIn
|
gptkb:World_Health_Organization's_List_of_Essential_Medicines
|
|
gptkbp:KEGGID
|
gptkb:D08402
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
disrupts bacterial cell membrane
|
|
gptkbp:metabolism
|
not significantly metabolized
|
|
gptkbp:molecularWeight
|
1,203.5 g/mol
|
|
gptkbp:notEffectiveAgainst
|
fungi
Gram-positive bacteria
|
|
gptkbp:origin
|
natural product
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:producedBy
|
gptkb:Bacillus_polymyxa
|
|
gptkbp:PubChem_CID
|
5311054
DB00781
CHEBI:8107
|
|
gptkbp:relatedTo
|
gptkb:colistin
|
|
gptkbp:resistanceReportedIn
|
gptkb:Pseudomonas_aeruginosa
gptkb:Acinetobacter_baumannii
gptkb:Klebsiella_pneumoniae
|
|
gptkbp:routeOfAdministration
|
topical
intramuscular
intravenous
|
|
gptkbp:sideEffect
|
nephrotoxicity
neurotoxicity
|
|
gptkbp:storage
|
store at 2–8°C
|
|
gptkbp:UNII
|
W6O6X3I6V5
|
|
gptkbp:usedFor
|
treatment of Gram-negative bacterial infections
|
|
gptkbp:bfsParent
|
gptkb:Neosporin
gptkb:Neomyxine
gptkb:Lipopolysaccharide
|
|
gptkbp:bfsLayer
|
7
|