|
gptkbp:instanceOf
|
gptkb:brand
gptkb:drug
|
|
gptkbp:activeIngredient
|
gptkb:chlorambucil
|
|
gptkbp:approvedBy
|
1950s
|
|
gptkbp:ATCCode
|
gptkb:L01AA02
|
|
gptkbp:CASNumber
|
1658-07-2
|
|
gptkbp:chemicalClass
|
nitrogen mustard
|
|
gptkbp:contraindication
|
pregnancy
hypersensitivity to chlorambucil
|
|
gptkbp:eliminationHalfLife
|
1.5 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:form
|
gptkb:tablet
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Leukeran
|
|
gptkbp:indication
|
malignant disease
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:manufacturer
|
gptkb:Aspen_Pharmacare
GlaxoSmithKline
|
|
gptkbp:mechanismOfAction
|
antineoplastic agent
|
|
gptkbp:MedlinePlusID
|
a682130
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
gptkb:D_(Australia)
D (US)
|
|
gptkbp:prescribes
|
autoimmune diseases (off-label)
veterinary use (cats, dogs)
|
|
gptkbp:PubChem_CID
|
gptkb:DB00291
2726
2624
|
|
gptkbp:riskFactor
|
teratogenicity
carcinogenicity
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:RxNormID
|
1978
|
|
gptkbp:sideEffect
|
gptkb:anemia
nausea
vomiting
thrombocytopenia
leukopenia
bone marrow suppression
|
|
gptkbp:storage
|
refrigerated
|
|
gptkbp:synonym
|
gptkb:CBL
gptkb:chlorambucil
NSC 3074
|
|
gptkbp:UNII
|
G9P1D3J5VU
|
|
gptkbp:usedFor
|
gptkb:cancer
gptkb:Waldenström's_macroglobulinemia
leukemia
Hodgkin lymphoma
chronic lymphocytic leukemia
|
|
gptkbp:bfsParent
|
gptkb:chlorambucil
|
|
gptkbp:bfsLayer
|
7
|