|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:affiliatedWith
|
amine oxidase family
|
|
gptkbp:alsoKnownAs
|
KDM1A
lysine-specific histone demethylase 1A
|
|
gptkbp:associatedWith
|
gptkb:neuroblastoma
gptkb:acute_myeloid_leukemia
prostate cancer
|
|
gptkbp:catalyzes
|
demethylation of mono- and dimethylated lysine 4 on histone H3 (H3K4me1/2)
demethylation of lysine 9 on histone H3 (H3K9me1/2) in certain contexts
|
|
gptkbp:cofactor
|
gptkb:FAD_(flavin_adenine_dinucleotide)
|
|
gptkbp:discoveredBy
|
gptkb:Shi_Yang
|
|
gptkbp:discoveredIn
|
2004
|
|
gptkbp:domain
|
SWIRM domain
amine oxidase domain
|
|
gptkbp:encodedBy
|
KDM1A gene
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:formsComplexWith
|
gptkb:HDAC2
gptkb:REST
gptkb:CoREST
gptkb:NuRD_complex
gptkb:HDAC1
|
|
gptkbp:function
|
epigenetic regulation
histone demethylation
|
|
gptkbp:gene
|
KDM1A
|
|
gptkbp:HGNC_ID
|
29079
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LSD1
|
|
gptkbp:inhibitedBy
|
gptkb:tranylcypromine
GSK2879552
ORY-1001
|
|
gptkbp:involvedIn
|
cell differentiation
embryonic development
cancer progression
gene expression regulation
|
|
gptkbp:locatedIn
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
1p36.12
|
|
gptkbp:molecularWeight
|
~92 kDa
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
2V1D
2HKO
2VID
|
|
gptkbp:regulates
|
transcriptional activation
chromatin structure
transcriptional repression
|
|
gptkbp:target
|
cancer therapeutics
epigenetic drugs
|
|
gptkbp:UniProtID
|
O60341
|
|
gptkbp:bfsParent
|
gptkb:ZNF217
gptkb:CoREST
|
|
gptkbp:bfsLayer
|
8
|