|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
KDM1A
lysine-specific histone demethylase 1A
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:acute_myeloid_leukemia
neurodevelopment
|
|
gptkbp:cofactor
|
gptkb:FAD
|
|
gptkbp:discoveredBy
|
2004
|
|
gptkbp:enzymeCommissionNumber
|
EC 1.14.99.66
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:formsComplexWith
|
gptkb:HDAC2
gptkb:REST
gptkb:CoREST
gptkb:HDAC1
|
|
gptkbp:function
|
epigenetic regulator
histone demethylase
|
|
gptkbp:gene
|
KDM1A
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LSD-1
|
|
gptkbp:inhibitedBy
|
gptkb:tranylcypromine
GSK2879552
ORY-1001
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_1p36.12
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
~92 kDa
|
|
gptkbp:mutationAssociatedWith
|
intellectual disability
developmental delay
|
|
gptkbp:organism
|
gptkb:human
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
2IW5
2V1D
2X0L
|
|
gptkbp:regulates
|
gene expression
chromatin structure
|
|
gptkbp:requires
|
embryonic development
stem cell pluripotency
|
|
gptkbp:structure
|
contains SWIRM domain
contains Tower domain
contains amine oxidase domain
|
|
gptkbp:substrate
|
gptkb:histone_H3_lysine_9_(H3K9)
histone H3 lysine 4 (H3K4)
|
|
gptkbp:target
|
anticancer drugs
epigenetic therapy
|
|
gptkbp:UniProtID
|
O60341
|
|
gptkbp:bfsParent
|
gptkb:USS_Ashland
|
|
gptkbp:bfsLayer
|
7
|