Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alias |
CD107a
|
| gptkbp:antibodyMarker |
used as a marker for degranulation in cytotoxic T cells and NK cells
|
| gptkbp:associatedWith |
gptkb:cancer
lysosomal storage disorders |
| gptkbp:biologicalProcess |
immune response
autophagy cell adhesion lysosome organization |
| gptkbp:cellularComponent |
lysosomal membrane
|
| gptkbp:discoveredBy |
1980s
|
| gptkbp:Entrez_Gene_ID |
ENSG00000005844
|
| gptkbp:expressedIn |
ubiquitous, especially in immune cells
|
| gptkbp:fullName |
Lysosome-associated membrane glycoprotein 1
|
| gptkbp:function |
involved in cell adhesion
involved in autophagy involved in lysosome biogenesis lysosomal membrane glycoprotein |
| gptkbp:gene |
gptkb:LAMP1
|
| gptkbp:glycosylation |
N-linked
O-linked |
| gptkbp:HGNC_ID |
HGNC:6485
|
| https://www.w3.org/2000/01/rdf-schema#label |
LAMP1
|
| gptkbp:interactsWith |
gptkb:NK_cells
gptkb:CD8+_T_cells LAMP2 |
| gptkbp:length |
417
|
| gptkbp:locatedOnChromosome |
gptkb:13q34
|
| gptkbp:molecularWeight |
120 kDa
|
| gptkbp:mutationAssociatedWith |
can affect immune cell degranulation
can affect lysosomal function |
| gptkbp:OMIM |
153612
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
mouse Lamp1
rat Lamp1 |
| gptkbp:pathway |
autophagy pathway
immune system pathway lysosome pathway |
| gptkbp:postTranslationalModification |
heavily glycosylated
|
| gptkbp:proteinFamily |
LAMP family
|
| gptkbp:RefSeq |
NM_005561
|
| gptkbp:structure |
type I transmembrane protein
|
| gptkbp:studiedBy |
marker for degranulation
marker for lysosomes |
| gptkbp:subcellularLocation |
gptkb:lysosome
plasma membrane (upon activation) |
| gptkbp:UniProtID |
P11279
|
| gptkbp:bfsParent |
gptkb:Endosome
gptkb:Lysosomal-associated_membrane_protein_(LAMP) gptkb:13q34 |
| gptkbp:bfsLayer |
7
|