Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:approved_drug_form |
gptkb:Aldurazyme
|
| gptkbp:biologicalProcess |
glycosidase activity
|
| gptkbp:CASNumber |
9025-39-2
|
| gptkbp:deficiencyCauses |
gptkb:Hurler_syndrome
gptkb:Mucopolysaccharidosis_type_I |
| gptkbp:discoveredBy |
1970s
|
| gptkbp:EC_number |
3.2.1.76
|
| gptkbp:function |
hydrolyzes alpha-L-iduronide residues in glycosaminoglycans
|
| gptkbp:gene |
gptkb:IDUA
|
| https://www.w3.org/2000/01/rdf-schema#label |
L-iduronidase
|
| gptkbp:locatedOnChromosome |
gptkb:4p16.3
|
| gptkbp:location |
gptkb:lysosome
|
| gptkbp:medicalUse |
enzyme replacement therapy
|
| gptkbp:OMIM |
252800
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:structure |
gptkb:protein
|
| gptkbp:substrate |
dermatan sulfate
heparan sulfate |
| gptkbp:UniProtID |
P35475
|
| gptkbp:bfsParent |
gptkb:alpha-L-iduronidase
|
| gptkbp:bfsLayer |
6
|