Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
growth factor |
| gptkbp:alternativeName |
gptkb:SCF
gptkb:mast_cell_growth_factor gptkb:steel_factor gptkb:MGF gptkb:stem_cell_factor |
| gptkbp:biologicalProcess |
cell differentiation
cell proliferation cell survival |
| gptkbp:discoveredIn |
1990
|
| gptkbp:encodedBy |
gptkb:KITLG_gene
|
| gptkbp:Entrez_Gene_ID |
4254
|
| gptkbp:function |
involved in gametogenesis
involved in melanogenesis stimulates hematopoietic stem cell proliferation binds to c-KIT receptor involved in mast cell development |
| gptkbp:GO |
GO:0005634 (nucleus)
GO:0005102 (signaling receptor binding) GO:0008284 (positive regulation of cell proliferation) |
| https://www.w3.org/2000/01/rdf-schema#label |
KIT ligand protein
|
| gptkbp:locatedOnChromosome |
chromosome 12q22
|
| gptkbp:medicalUse |
potential target in cancer therapy
used in stem cell mobilization |
| gptkbp:molecularWeight |
~30 kDa (soluble form)
|
| gptkbp:mutationAssociatedWith |
mutations can cause anemia
mutations can cause infertility mutations can cause piebaldism |
| gptkbp:OMIM |
184745
|
| gptkbp:orthologIn |
present in mouse
present in rat present in zebrafish |
| gptkbp:pathway |
germ cell development
hematopoiesis melanocyte development |
| gptkbp:PDB |
2E9W
|
| gptkbp:postTranslationalModification |
glycosylation
proteolytic cleavage |
| gptkbp:recipient |
gptkb:c-KIT_(CD117)
|
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structure |
exists as both soluble and membrane-bound forms
|
| gptkbp:tissue_specificity |
gptkb:skin
gptkb:placenta gptkb:testis bone marrow fetal liver |
| gptkbp:UniProtID |
P21583
|
| gptkbp:bfsParent |
gptkb:KITLG
gptkb:KITLG_gene |
| gptkbp:bfsLayer |
8
|