KDM4C

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alsoKnownAs JHDM3C
JMJD2C
gptkbp:associatedWith gptkb:cancer
gptkbp:biologicalProcess chromatin modification
regulation of transcription
histone demethylase activity
gptkbp:cofactor gptkb:2-oxoglutarate
Fe(II)
gptkbp:discoveredBy Yamane et al.
gptkbp:discoveredIn 2006
gptkbp:domain gptkb:Tudor_domain
PHD-type zinc finger
JmjC domain
gptkbp:encodes KDM4C protein
gptkbp:Entrez_Gene_ID 9682
ENSG00000172057
gptkbp:expressedIn gptkb:nucleus
gptkbp:fullName Lysine Demethylase 4C
gptkbp:function histone demethylase
gptkbp:geneType protein-coding
gptkbp:GOID GO:0003677
GO:0032452
gptkbp:hasParalog gptkb:KDM4B
KDM4A
KDM4D
gptkbp:HGNC_ID HGNC:29000
https://www.w3.org/2000/01/rdf-schema#label KDM4C
gptkbp:involvedIn epigenetic regulation
gptkbp:length 1064 amino acids
gptkbp:locatedOnChromosome gptkb:9p24.1
gptkbp:molecularWeight 120 kDa
gptkbp:mutationAssociatedWith gptkb:autism_spectrum_disorder
schizophrenia
intellectual disability
gptkbp:OMIM 609765
gptkbp:orthologInMouse Kdm4c
gptkbp:overexpressedIn gptkb:cancer
prostate cancer
esophageal squamous cell carcinoma
gptkbp:regulates gene expression
chromatin structure
gptkbp:removesMethylationFrom gptkb:H3K36me3
gptkb:H3K9me3
gptkbp:species gptkb:Homo_sapiens
gptkbp:subcellularLocation gptkb:nucleus
gptkbp:target small molecule inhibitors
gptkbp:UniProtID Q9H3R0
gptkbp:bfsParent gptkb:9p24.1
gptkbp:bfsLayer 7