|
gptkbp:instanceOf
|
gptkb:protein
hormone
|
|
gptkbp:administeredBy
|
injection
|
|
gptkbp:approvedForUse
|
1922
|
|
gptkbp:ATCCode
|
A10AB01
|
|
gptkbp:CASNumber
|
11061-68-0
|
|
gptkbp:chainA
|
21 amino acids
|
|
gptkbp:chainB
|
30 amino acids
|
|
gptkbp:cleavage
|
gptkb:C-peptide
|
|
gptkbp:deficiencyCauses
|
gptkb:diabetes_mellitus
|
|
gptkbp:degradedBy
|
insulinase
|
|
gptkbp:discoveredBy
|
gptkb:Frederick_Banting
gptkb:Charles_Best
|
|
gptkbp:discoveredIn
|
1921
|
|
gptkbp:encodedBy
|
gptkb:INS_gene
|
|
gptkbp:firstTherapeuticUse
|
Leonard Thompson
|
|
gptkbp:form
|
monomer
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
lowers blood sugar
inhibits gluconeogenesis
promotes fat storage
promotes glucose uptake
stimulates glycogen synthesis
|
|
gptkbp:halfLife
|
4-6 minutes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Insulin (human)
|
|
gptkbp:inhibitedBy
|
gptkb:somatostatin
epinephrine
|
|
gptkbp:linkedBy
|
disulfide bonds
|
|
gptkbp:MeSH_ID
|
D007328
|
|
gptkbp:molecularWeight
|
5808 Da
|
|
gptkbp:orthologIn
|
other mammals
|
|
gptkbp:pI
|
5.3
|
|
gptkbp:predecessor
|
proinsulin
|
|
gptkbp:producedBy
|
pancreas
beta cells
|
|
gptkbp:promotion
|
glucose
amino acids
fatty acids
|
|
gptkbp:PubChem_CID
|
16132288
DB00030
|
|
gptkbp:recipient
|
gptkb:insulin_receptor
|
|
gptkbp:regulates
|
blood glucose
|
|
gptkbp:sequence
|
51 amino acids
|
|
gptkbp:solubility
|
water soluble
|
|
gptkbp:storage
|
hexamer
|
|
gptkbp:structure
|
two polypeptide chains
|
|
gptkbp:synthesisType
|
recombinant DNA technology
|
|
gptkbp:UNII
|
IY9XDZ35W2
|
|
gptkbp:usedAs
|
gptkb:drug
|
|
gptkbp:usedFor
|
gptkb:gestational_diabetes
gptkb:type_2_diabetes
type 1 diabetes
|
|
gptkbp:bfsParent
|
gptkb:DB00005
gptkb:DB00065
|
|
gptkbp:bfsLayer
|
7
|