|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:ATCCode
|
A10AB01
|
|
gptkbp:CASNumber
|
11061-68-0
|
|
gptkbp:contraindication
|
gptkb:Hypersensitivity_to_insulin
|
|
gptkbp:halfLife
|
4-6 minutes (plasma)
|
|
gptkbp:hasEliminationRoute
|
Hepatic
Renal
|
|
gptkbp:hasMolecularFormula
|
C257H383N65O77S6
|
|
gptkbp:hasPharmacodynamics
|
Lowers blood glucose by facilitating cellular glucose uptake
|
|
gptkbp:hasUNII
|
1F7A44V6OU
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB00005
|
|
gptkbp:indication
|
gptkb:Gestational_diabetes
gptkb:Type_1_diabetes_mellitus
gptkb:Type_2_diabetes_mellitus
|
|
gptkbp:isApprovedDrug
|
true
|
|
gptkbp:isBiotechDrug
|
true
|
|
gptkbp:mechanismOfAction
|
Binds to insulin receptor and stimulates glucose uptake
|
|
gptkbp:metabolism
|
Liver
Kidney
|
|
gptkbp:molecularWeight
|
5808.0
|
|
gptkbp:name
|
gptkb:Insulin_(human)
|
|
gptkbp:PDB
|
gptkb:4EZA
gptkb:4EZC
gptkb:4EZD
gptkb:4EZE
gptkb:4EZI
gptkb:4EZK
gptkb:4EZL
gptkb:4EZM
gptkb:4EZO
gptkb:4EZP
gptkb:4EZR
gptkb:4EZS
gptkb:4EZT
gptkb:4EZX
gptkb:4EZY
gptkb:4EZZ
gptkb:4EWW
4EYJ
1ZNJ
4EY1
4EY9
4EYD
4EYF
4EYI
4EYQ
4EYR
4EYS
4EYT
4EYU
4EYV
4EYW
4EYX
4EYY
4EYZ
4EZ0
4EZ1
4EZ2
4EZ3
4EZ4
4EZ5
4EZ6
4EZ7
4EZ8
4EZ9
4EZB
4EZF
4EZG
4EZH
4EZJ
4EZN
4EZQ
4EZU
4EZV
4EZW
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:proteinBinding
|
Low
|
|
gptkbp:PubChem_CID
|
gptkb:DB00005
101896409
CHEMBL1201618
D04468
|
|
gptkbp:routeOfAdministration
|
intramuscular
subcutaneous
intravenous
|
|
gptkbp:sideEffect
|
gptkb:Lipodystrophy
Allergic reactions
Hypoglycemia
|
|
gptkbp:status
|
true
|
|
gptkbp:synonym
|
gptkb:Actrapid
gptkb:Humulin
gptkb:Insulatard
gptkb:Insuman
gptkb:Novolin
gptkb:Velosulin
gptkb:Insulin,_human
gptkb:Insulin_injection
Recombinant human insulin
|
|
gptkbp:target
|
gptkb:Insulin_receptor
|
|
gptkbp:bfsParent
|
gptkb:Enbrel
|
|
gptkbp:bfsLayer
|
6
|