|
gptkbp:instanceOf
|
neurological disorder
|
|
gptkbp:affects
|
central nervous system
motor function
non-motor function
|
|
gptkbp:alsoKnownAs
|
gptkb:Parkinson's_disease
|
|
gptkbp:associatedWith
|
Lewy bodies
|
|
gptkbp:causedBy
|
degeneration of dopaminergic neurons in substantia nigra
|
|
gptkbp:characterizedBy
|
bradykinesia
postural instability
resting tremor
muscle rigidity
|
|
gptkbp:complication
|
gptkb:dementia
gptkb:pneumonia
falls
autonomic dysfunction
|
|
gptkbp:diagnosedBy
|
clinical examination
response to dopaminergic therapy
|
|
gptkbp:differentialDiagnosis
|
gptkb:corticobasal_degeneration
gptkb:multiple_system_atrophy
gptkb:progressive_supranuclear_palsy
drug-induced parkinsonism
|
|
gptkbp:firstDescribed
|
gptkb:James_Parkinson
1817
|
|
gptkbp:hasNoKnownCause
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Idiopathic Parkinsonism
|
|
gptkbp:ICD-10_code
|
gptkb:G20
|
|
gptkbp:MeSH_ID
|
D010300
|
|
gptkbp:OMIM
|
168600
|
|
gptkbp:prevalence
|
1% of people over 60 years old
|
|
gptkbp:prognosis
|
variable
|
|
gptkbp:progression
|
chronic and progressive
|
|
gptkbp:riskFactor
|
age
family history
male sex
|
|
gptkbp:symptom
|
gptkb:depression
shuffling gait
cognitive impairment
hypophonia
masked facies
micrographia
|
|
gptkbp:treatment
|
gptkb:levodopa
MAO-B inhibitors
deep brain stimulation
dopamine agonists
|
|
gptkbp:bfsParent
|
gptkb:D010141
|
|
gptkbp:bfsLayer
|
7
|