|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:discoveredBy
|
gptkb:Toshio_Hirano
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodedBy
|
gptkb:IL6_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000136244
3569
|
|
gptkbp:fullName
|
Interleukin 6
|
|
gptkbp:function
|
stimulates immune response
induces fever
anti-inflammatory cytokine
pro-inflammatory cytokine
stimulates acute phase protein production
|
|
gptkbp:gene
|
gptkb:IL6
|
|
gptkbp:halfLife
|
~1.5 hours
|
|
gptkbp:HGNC_ID
|
6018
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL 6
|
|
gptkbp:inducedBy
|
B cell differentiation
C-reactive protein production
hepcidin production
|
|
gptkbp:involves
|
gptkb:systemic_lupus_erythematosus
gptkb:Castleman's_disease
multiple myeloma
rheumatoid arthritis
COVID-19 cytokine storm
|
|
gptkbp:length
|
212
|
|
gptkbp:locatedOnChromosome
|
7p15.3
|
|
gptkbp:molecularWeight
|
23.7 kDa
|
|
gptkbp:OMIM
|
147620
|
|
gptkbp:PDB
|
gptkb:1ALU
|
|
gptkbp:producedBy
|
gptkb:T_cells
macrophages
endothelial cells
fibroblasts
|
|
gptkbp:recipient
|
gptkb:gp130
IL-6 receptor (IL-6R)
|
|
gptkbp:RefSeq
|
gptkb:NM_000600
|
|
gptkbp:regulates
|
metabolism
inflammation
immune response
hematopoiesis
|
|
gptkbp:secretes
|
in response to infection
in response to trauma
|
|
gptkbp:structure
|
four-helix bundle
|
|
gptkbp:target
|
gptkb:tocilizumab
gptkb:sarilumab
gptkb:siltuximab
|
|
gptkbp:UniProtID
|
gptkb:P05231
|
|
gptkbp:bfsParent
|
gptkb:Illinois_Route_6
|
|
gptkbp:bfsLayer
|
8
|