|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CD125
IL-5R-alpha
IL5R
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:eosinophilic_asthma
gptkb:eosinophilic_granulomatosis_with_polyangiitis
asthma
hypereosinophilic syndrome
eosinophil activation
allergic diseases
chronic eosinophilic leukemia
|
|
gptkbp:biologicalProcess
|
cell signaling
immune response
cytokine receptor activity
|
|
gptkbp:component
|
IL-5 receptor complex
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
IL5RA protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000113525
3568
|
|
gptkbp:expressedIn
|
gptkb:basophils
gptkb:mast_cells
gptkb:eosinophils
|
|
gptkbp:fullName
|
interleukin 5 receptor subunit alpha
|
|
gptkbp:function
|
cytokine receptor activity
interleukin-5 binding
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
6017
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL5RA gene
|
|
gptkbp:length
|
~20 kb
approximately 420 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3
3p26.2
|
|
gptkbp:mutationAssociatedWith
|
eosinophilia
allergic asthma
|
|
gptkbp:numberOfExons
|
14
|
|
gptkbp:OMIM
|
147851
|
|
gptkbp:orthologInMouse
|
Il5ra
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
cytokine-cytokine receptor interaction
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:symbol
|
IL5RA
|
|
gptkbp:targetOfDrug
|
gptkb:benralizumab
gptkb:mepolizumab
gptkb:reslizumab
|
|
gptkbp:UniProtID
|
Q01344
|
|
gptkbp:bfsParent
|
gptkb:interleukin-5_receptor_alpha
gptkb:IL-5_receptor
|
|
gptkbp:bfsLayer
|
7
|