|
gptkbp:instanceOf
|
gptkb:cytokine
gptkb:protein
|
|
gptkbp:alias
|
gptkb:ALRH
gptkb:NC30
gptkb:interleukin-13
P600
BHR1
|
|
gptkbp:associatedWith
|
gptkb:atopic_dermatitis
asthma
ulcerative colitis
idiopathic pulmonary fibrosis
allergic rhinitis
|
|
gptkbp:discoveredBy
|
gptkb:William_E._Paul
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodes
|
gptkb:Interleukin-13
|
|
gptkbp:enemyOf
|
gptkb:lebrikizumab
gptkb:tralokinumab
gptkb:dupilumab
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000169194
3596
|
|
gptkbp:expressedIn
|
gptkb:basophils
gptkb:mast_cells
gptkb:T_helper_2_cells
gptkb:eosinophils
|
|
gptkbp:function
|
IgE synthesis
regulation of immune response
B cell maturation
inhibition of inflammatory cytokines
|
|
gptkbp:gene
|
gptkb:IL13
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:5973
|
|
gptkbp:length
|
146 amino acids
|
|
gptkbp:locatedOnChromosome
|
5
5q31.1
|
|
gptkbp:molecularWeight
|
13 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
IL13 (mouse)
IL13 (rat)
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
cytokine-cytokine receptor interaction
|
|
gptkbp:postTranslationalModification
|
gptkb:N-glycosylation
disulfide bond formation
|
|
gptkbp:recipient
|
gptkb:IL13RA1
gptkb:IL13RA2
|
|
gptkbp:regulates
|
inflammation
fibrosis
mucus production
airway hyperresponsiveness
macrophage activation
IgE class switching
goblet cell hyperplasia
smooth muscle contractility
|
|
gptkbp:structure
|
four-helix bundle
|
|
gptkbp:UniProtID
|
gptkb:P35225
|
|
gptkbp:bfsParent
|
gptkb:Il13
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL13 (human)
|