|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:category
|
cytokine
|
|
gptkbp:discoveredBy
|
gptkb:Andrew_N.J._McKenzie
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:IL13_gene
|
|
gptkbp:enemyOf
|
IL-13Rα2
|
|
gptkbp:Entrez_Gene_ID
|
GC13P132
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
regulation of immune response
B cell maturation
IgE class switching
inhibition of inflammatory cytokines
|
|
gptkbp:gene
|
gptkb:IL13
|
|
gptkbp:HGNC_ID
|
6014
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Interleukin-13
|
|
gptkbp:involvedIn
|
gptkb:atopic_dermatitis
airway hyperresponsiveness
allergic asthma
type 2 immune response
|
|
gptkbp:length
|
132 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5q31
|
|
gptkbp:molecularWeight
|
14 kDa
|
|
gptkbp:OMIM
|
147683
|
|
gptkbp:orthologInMouse
|
gptkb:Il13
|
|
gptkbp:PDB
|
1IJZ
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
|
gptkbp:producedBy
|
gptkb:basophils
gptkb:mast_cells
gptkb:T_helper_2_cells
gptkb:eosinophils
|
|
gptkbp:recipient
|
gptkb:IL-13_receptor_alpha_1
gptkb:IL-13_receptor_alpha_2
|
|
gptkbp:regulates
|
mucus production
eosinophil recruitment
macrophage activation
fibroblast proliferation
goblet cell hyperplasia
collagen deposition
|
|
gptkbp:relatedTo
|
gptkb:interleukin-4
asthma
fibrosis
allergic inflammation
|
|
gptkbp:structure
|
four-helix bundle
|
|
gptkbp:symbol
|
gptkb:IL-13
|
|
gptkbp:target
|
gptkb:lebrikizumab
gptkb:tralokinumab
gptkb:dupilumab
|
|
gptkbp:UniProtID
|
gptkb:P35225
|
|
gptkbp:bfsParent
|
gptkb:IL-13
|
|
gptkbp:bfsLayer
|
7
|