|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:drug
|
|
gptkbp:administeredBy
|
gptkb:tablet
capsule
|
|
gptkbp:ATCCode
|
L01XX05
|
|
gptkbp:CASNumber
|
127-07-1
|
|
gptkbp:category
|
antineoplastic agent
orphan drug
|
|
gptkbp:chemicalFormula
|
CH4N2O2
|
|
gptkbp:color
|
white
|
|
gptkbp:contraindication
|
pregnancy
severe bone marrow depression
|
|
gptkbp:discoveredBy
|
1869
|
|
gptkbp:eliminationHalfLife
|
3-4 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:FDAApproved
|
yes
|
|
gptkbp:first_medical_use
|
1960s
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Hydroxyurea
|
|
gptkbp:included_in_WHO_Model_List_of_Essential_Medicines
|
yes
|
|
gptkbp:KEGGID
|
D00341
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits ribonucleotide reductase
|
|
gptkbp:meltingPoint
|
132°C
|
|
gptkbp:MeSH_ID
|
D006818
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
76.05 g/mol
|
|
gptkbp:origin
|
synthetic
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:PubChem_CID
|
3657
CHEMBL467
DB01005
|
|
gptkbp:riskFactor
|
teratogenicity
carcinogenicity
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
hair loss
bone marrow suppression
skin ulcer
|
|
gptkbp:solubility
|
very soluble
|
|
gptkbp:synonym
|
gptkb:hydroxycarbamide
urea, N-hydroxy-
|
|
gptkbp:UNII
|
X6Q56QN7X0
|
|
gptkbp:usedFor
|
gptkb:chronic_myelogenous_leukemia
gptkb:sickle_cell_anemia
gptkb:polycythemia_vera
essential thrombocythemia
|
|
gptkbp:bfsParent
|
gptkb:Sickle_Cells
|
|
gptkbp:bfsLayer
|
8
|