|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:drug
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
L01XX05
|
|
gptkbp:boilingPoint
|
decomposes before boiling
|
|
gptkbp:CASNumber
|
127-07-1
|
|
gptkbp:color
|
white
|
|
gptkbp:contraindication
|
pregnancy
severe bone marrow depression
|
|
gptkbp:discoveredIn
|
1869
|
|
gptkbp:drugClass
|
antineoplastic agent
|
|
gptkbp:eliminatedIn
|
renal
|
|
gptkbp:eliminationHalfLife
|
3-4 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasInChIKey
|
VWGRFVHCWWPSQG-UHFFFAOYSA-N
|
|
gptkbp:hasMolecularFormula
|
CH4N2O2
|
|
gptkbp:hasSMILES
|
C(=O)(N)NO
|
|
gptkbp:hasUNII
|
X6Q56QN7X0
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
hydroxycarbamide
|
|
gptkbp:isOnWHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:IUPACName
|
gptkb:hydroxyurea
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits ribonucleotide reductase
|
|
gptkbp:meltingPoint
|
132°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
76.05 g/mol
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:PubChem_CID
|
3531
3657
DB01005
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
hair loss
bone marrow suppression
skin ulcer
|
|
gptkbp:solubility
|
very soluble
|
|
gptkbp:synonym
|
gptkb:Droxia
gptkb:Hydrea
gptkb:Siklos
gptkb:hydroxyurea
|
|
gptkbp:usedFor
|
gptkb:chronic_myelogenous_leukemia
gptkb:polycythemia_vera
sickle cell disease
essential thrombocythemia
|
|
gptkbp:bfsParent
|
gptkb:hydroxyurea
|
|
gptkbp:bfsLayer
|
6
|