Statements (80)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Genetics
|
| gptkbp:advocacy |
gptkb:Sickle_Cell_Anemia_Association_of_New_Jersey
gptkb:Sickle_Cell_Disease_Coalition gptkb:Sickle_Cell_Society gptkb:Sickle_Cell_Disease_Association_of_America gptkb:Sickle_Cell_Foundation |
| gptkbp:affects |
red blood cells
both genders |
| gptkbp:archaeological_findings |
discovered in 1910
first described by James B. Herrick |
| gptkbp:associated_with |
stroke
chronic pain pulmonary hypertension heart problems blood clots increased risk of infections gallstones pregnancy complications kidney problems spleen dysfunction reduced life expectancy acute chest syndrome leg ulcers liver complications |
| gptkbp:can_lead_to |
gptkb:anemia
increased risk of infections pain crises |
| gptkbp:caused_by |
mutation in HBB gene
mutation in hemoglobin gene |
| gptkbp:characterized_by |
abnormal hemoglobin structure
|
| gptkbp:community_impact |
affects millions worldwide
public health concern influences healthcare policies requires international collaboration more common in tropical regions |
| gptkbp:complication |
stroke
pulmonary hypertension organ damage acute chest syndrome leg ulcers |
| gptkbp:cultural_impact |
gptkb:educational_programs
support groups awareness campaigns research funding initiatives advocacy organizations |
| gptkbp:diagnosis |
blood test
hemoglobin electrophoresis |
| gptkbp:first_described_by |
gptkb:James_B._Herrick
|
| gptkbp:genetic_counseling_recommended_for |
affected families
|
| gptkbp:genetic_disorder |
yes
|
| https://www.w3.org/2000/01/rdf-schema#label |
sickle cell anemia
|
| gptkbp:inherits_from |
gptkb:parents
|
| gptkbp:is_often_seen_in |
African descent
Mediterranean descent Indian descent Middle Eastern descent |
| gptkbp:public_awareness |
important
|
| gptkbp:research_focus |
gptkb:gene_therapy
patient education preventive care new medications pain management |
| gptkbp:screenings |
newborns
newborn screening high-risk populations |
| gptkbp:symptoms |
gptkb:anemia
fatigue vision problems frequent infections pain crises swelling in hands and feet delayed growth |
| gptkbp:treatment |
bone marrow transplant
hydroxyurea blood transfusions |
| gptkbp:type |
gptkb:sickle_cell_disease
sickle cell trait |
| gptkbp:bfsParent |
gptkb:TLC
gptkb:Prodigy |
| gptkbp:bfsLayer |
5
|