|
gptkbp:instanceOf
|
gptkb:Corticosteroid
|
|
gptkbp:approvedBy
|
gptkb:FDA
1952
|
|
gptkbp:ATCCode
|
H02AB09
|
|
gptkbp:availableOn
|
gptkb:butter
gptkb:hospital
gptkb:tablet
injection
|
|
gptkbp:brand
|
Cortef
Hydrocortone
Solu-Cortef
|
|
gptkbp:CASNumber
|
50-23-7
|
|
gptkbp:chemicalFormula
|
C21H30O5
|
|
gptkbp:contraindication
|
hypersensitivity
systemic fungal infections
|
|
gptkbp:discoveredBy
|
gptkb:Edward_Calvin_Kendall
|
|
gptkbp:drugClass
|
gptkb:Corticosteroid
|
|
gptkbp:eliminationHalfLife
|
1.5-2 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:foundIn
|
gptkb:World_Health_Organization's_List_of_Essential_Medicines
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Hydrocortisone
|
|
gptkbp:interactsWith
|
gptkb:insulin
gptkb:phenytoin
gptkb:rifampin
gptkb:warfarin
vaccines
|
|
gptkbp:IUPACName
|
(11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
anti-inflammatory
immunosuppressive
binds to glucocorticoid receptor
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
362.46 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:producedBy
|
adrenal cortex
|
|
gptkbp:routeOfAdministration
|
oral
topical
intravenous
rectal
|
|
gptkbp:sideEffect
|
gptkb:bone
immunosuppression
hypertension
weight gain
hyperglycemia
|
|
gptkbp:synonym
|
gptkb:Cortisol
|
|
gptkbp:usedFor
|
autoimmune diseases
allergic reactions
adrenal insufficiency
inflammatory conditions
topical skin conditions
|
|
gptkbp:bfsParent
|
gptkb:Cortisone
gptkb:Corticosteroid
|
|
gptkbp:bfsLayer
|
6
|