Statements (102)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
hormone
Steroid hormone class of steroid hormones |
| gptkbp:affects |
Carbohydrate metabolism
Fat metabolism Protein metabolism |
| gptkbp:alternativeName |
Glucocorticoid
corticosteroid glucocorticoid steroid |
| gptkbp:category |
gptkb:pharmacy
Immunology Endocrinology |
| gptkbp:contraindication |
systemic fungal infection
live vaccines |
| gptkbp:discoveredBy |
gptkb:Edward_Calvin_Kendall
gptkb:Tadeus_Reichstein gptkb:Philip_S._Hench |
| gptkbp:discoveredIn |
1930s
|
| gptkbp:enemyOf |
gptkb:Hydrocortisone
gptkb:Prednisolone gptkb:Dexamethasone gptkb:Mifepristone |
| gptkbp:example |
gptkb:prednisone
gptkb:aldosterone gptkb:Corticosterone gptkb:Prednisone gptkb:dexamethasone gptkb:methylprednisolone gptkb:fludrocortisone gptkb:Cortisol gptkb:betamethasone gptkb:Dexamethasone cortisol hydrocortisone triamcinolone |
| gptkbp:excretion |
kidneys
|
| gptkbp:foundIn |
gptkb:Vertebrates
|
| gptkbp:hasChemicalStructure |
Steroid nucleus
|
| https://www.w3.org/2000/01/rdf-schema#label |
Corticosteroid
|
| gptkbp:influenced |
gptkb:Gluconeogenesis
Protein catabolism Blood pressure Lipolysis Bone resorption Mood and behavior Water balance |
| gptkbp:inhibitedBy |
Inflammatory cytokine production
Leukocyte migration |
| gptkbp:mechanismOfAction |
Binds to glucocorticoid receptor
binds to glucocorticoid receptor binds to mineralocorticoid receptor |
| gptkbp:metabolism |
liver
|
| gptkbp:producedBy |
gptkb:Adrenal_cortex
adrenal cortex |
| gptkbp:recipient |
gptkb:Glucocorticoid_receptor
|
| gptkbp:regulates |
gptkb:Stress_response
metabolism inflammation immune response Metabolism stress response Immune response electrolyte balance Adrenocorticotropic hormone (ACTH) |
| gptkbp:routeOfAdministration |
oral
topical intramuscular intravenous intra-articular inhaled |
| gptkbp:sideEffect |
gptkb:bone
gptkb:Cushing's_syndrome immunosuppression hypertension peptic ulcer mood changes weight gain Hypertension Hyperglycemia Immunosuppression hyperglycemia Osteoporosis adrenal suppression |
| gptkbp:subclassOf |
gptkb:Corticosteroid
mineralocorticoid |
| gptkbp:syntheticForm |
gptkb:budesonide
gptkb:prednisolone beclomethasone |
| gptkbp:usedFor |
immunosuppression
Immunosuppression anti-inflammatory therapy treatment of asthma treatment of autoimmune diseases Anti-inflammatory therapy treatment of allergies Treatment of asthma treatment of adrenal insufficiency Treatment of allergies Treatment of autoimmune diseases |
| gptkbp:bfsParent |
gptkb:dexamethasone
|
| gptkbp:bfsLayer |
5
|